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Telpoukhovskaia, M.A.* ; Murdy, T.J.* ; Marola, O.J.* ; Charland, K.* ; MacLean, M.* ; Luquez, T.* ; Lish, A.M.* ; Neuner, S.* ; Dunn, A.* ; Onos, K.D.* ; Wiley, J.* ; Archer, D.* ; Huentelman, M.J.* ; Arnold, M. ; Menon, V.* ; Goate, A.* ; Van Eldik, L.J.* ; Territo, P.R.* ; Howell, G.R.* ; Carter, G.W.* ; O'Connell, K.M.S.* ; Kaczorowski, C.C.*

New directions for Alzheimer's disease research from the Jackson Laboratory Center for Alzheimer's and Dementia Research 2022 workshop.

Alzheimers Dement. 10:e12458 (2024)
Publ. Version/Full Text Research data DOI PMC
Open Access Hybrid
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INTRODUCTION: In September 2022, The Jackson Laboratory Center for Alzheimer's and Dementia Research (JAX CADR) hosted a workshop with leading researchers in the Alzheimer's disease and related dementias (ADRD) field. METHODS: During the workshop, the participants brainstormed new directions to overcome current barriers to providing patients with effective ADRD therapeutics. The participants outlined specific areas of focus. Following the workshop, each group used standard literature search methods to provide background for each topic. RESULTS: The team of invited experts identified four key areas that can be collectively addressed to make a significant impact in the field: (1) Prioritize the diversification of disease targets, (2) enhance factors promoting resilience, (3) de-risk clinical pipeline, and (4) centralize data management. DISCUSSION: In this report, we review these four objectives and propose innovations to expedite ADRD therapeutic pipelines.
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Publication type Article: Journal article
Document type Review
Keywords Alzheimers-disease; Connectivity Map; Resilience; Pathways
Language english
Publication Year 2024
HGF-reported in Year 2024
ISSN (print) / ISBN 1552-5260
e-ISSN 1552-5279
Journal Alzheimer's & Dementia
Quellenangaben Volume: 10, Issue: 1, Pages: , Article Number: e12458 Supplement: ,
Publisher Elsevier
Publishing Place New York, NY [u.a.]
Reviewing status Peer reviewed
Institute(s) Institute of Computational Biology (ICB)
POF-Topic(s) 30205 - Bioengineering and Digital Health
Research field(s) Enabling and Novel Technologies
PSP Element(s) G-503891-001
Grants National Institute of Health/National Institute on Aging
National Institute on Aging
National Institutes of Health
National Institute of Aging
Alzheimer's Association Zenith Fellows Award
JAX Center for Alzheimer's and Dementia Research (CADR)

Alzheimer's Association
DOI 10.1002/trc2.12458
WOS ID 001181630700001
WOS ID 001191400700002
Scopus ID 85187174689
PubMed ID 38469553
Erfassungsdatum 2024-05-08
[➜Report correction]