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Telpoukhovskaia, M.A.* ; Murdy, T.J.* ; Marola, O.J.* ; Charland, K.* ; MacLean, M.* ; Luquez, T.* ; Lish, A.M.* ; Neuner, S.* ; Dunn, A.* ; Onos, K.D.* ; Wiley, J.* ; Archer, D.* ; Huentelman, M.J.* ; Arnold, M. ; Menon, V.* ; Goate, A.* ; Van Eldik, L.J.* ; Territo, P.R.* ; Howell, G.R.* ; Carter, G.W.* ; O'Connell, K.M.S.* ; Kaczorowski, C.C.*

New directions for Alzheimer's disease research from the Jackson Laboratory Center for Alzheimer's and Dementia Research 2022 workshop.

Alzheimers Dement. 10:e12458 (2024)

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INTRODUCTION: In September 2022, The Jackson Laboratory Center for Alzheimer's and Dementia Research (JAX CADR) hosted a workshop with leading researchers in the Alzheimer's disease and related dementias (ADRD) field. METHODS: During the workshop, the participants brainstormed new directions to overcome current barriers to providing patients with effective ADRD therapeutics. The participants outlined specific areas of focus. Following the workshop, each group used standard literature search methods to provide background for each topic. RESULTS: The team of invited experts identified four key areas that can be collectively addressed to make a significant impact in the field: (1) Prioritize the diversification of disease targets, (2) enhance factors promoting resilience, (3) de-risk clinical pipeline, and (4) centralize data management. DISCUSSION: In this report, we review these four objectives and propose innovations to expedite ADRD therapeutic pipelines.

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Publication type Article: Journal article

Document type Review

Corresponding Author

Keywords Alzheimers-disease; Connectivity Map; Resilience; Pathways

ISSN (print) / ISBN 1552-5260

e-ISSN 1552-5279

Journal Alzheimer's & Dementia

Quellenangaben Volume: 10, Issue: 1, Article Number: e12458

Publisher Elsevier

Publishing Place New York, NY [u.a.]

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Computational Biology (ICB)

Grants National Institute of Health/National Institute on Aging
National Institute on Aging
National Institutes of Health
National Institute of Aging
Alzheimer's Association Zenith Fellows Award
JAX Center for Alzheimer's and Dementia Research (CADR)

Alzheimer's Association