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Guan, C.* ; Li, C.* ; Yang, C.* ; Yang, D.* ; Zhang, L.* ; Xu, L.* ; Liu, K.* ; Zhang, N.* ; Li, T.* ; Song, Z.* ; Che, L.* ; Wang, Y.* ; Zhang, L. ; Li, D.* ; Zhu, Y.* ; Xu, Y.*

Enhanced renal carcinomat treatment via synergistic photothermal/photodynamic therapy using hittorf's phosphorus-decorated polymeric carbon nitride heterostructure.

Adv. Opt. Mater. 2024:2303318 (2024)

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	Open Access Gold (Paid Option)

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Nanostructured heterojunctions offer a promising solution to overcome the limitations of narrow absorption spectra, limited penetration depths, and potential harm to healthy cells in phototherapy for clear cell renal cell carcinoma (ccRCC) treatment with nanomaterials. In this study, a heterostructure (PCN@HP) by decorating Hittorf's phosphorus nanorods onto biocompatible polymeric carbon nitride (PCN), enabling excitation by NIR light is designed. Compared with PCN and HP alone, the synthesized heterostructure generated localized heat upon broad absorption spectra of irradiation, boosting charge migration and separation, generating cytotoxic reactive oxygen species (ROS). Then, via in vitro and in vivo experiments, it is confirmed that the NIR-mediated PCN@HP heterojunction is a safe and effective approach for synchronous photothermal and photodynamic therapy treatment of ccRCC. Collectively, the PCN@HP heterojunction holds great potential as a non-invasive synergistic, dual-mode therapeutic nanomedicine for efficient tumor nano-therapy.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Clear Cell Renal Cell Carcinoma ; Hittorf's Phosphorus ; Mild Photothermal Therapy ; Photodynamic Therapy; Photothermal Therapy; Cell Carcinoma; Photodynamic Therapy; Tumor; Nanoparticles; Nanomaterials; Resistance

ISSN (print) / ISBN 2195-1071

e-ISSN 2195-1071

Journal Advanced Optical Materials

Quellenangaben Volume: 2024, Article Number: 2303318

Publisher Wiley

Publishing Place Postfach 101161, 69451 Weinheim, Germany

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Helmholtz Pioneer Campus (HPC)