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Wang, F.* ; Zhong, Y.* ; Bruns, O.T. ; Liang, Y.* ; Dai, H.*

In vivo NIR-II fluorescence imaging for biology and medicine.

Nat. Photonics, DOI: 10.1038/s41566-024-01391-5 (2024)
DOI
Owing to reduced light scattering and tissue autofluorescence, in vivo fluorescence imaging in the 1,000–3,000-nm near-infrared II (NIR-II) spectral range can afford non-invasive imaging at depths of millimetres within biological tissue. Infrared fluorescent probes labelled with antibodies or other targeting ligands also enable NIR-II molecular imaging at the single-cell level. Here we present recent developments in the design of fluorophores and probes emitting in the NIR-II window based on organic synthesis and nanoscience approaches. We also review advances in NIR-II wide-field and microscopy imaging modalities, with a focus on preclinical imaging and promising clinical translation case studies. Finally, we outline current issues and challenges for the wider adoption of NIR-II imaging in biomedical research and clinical imaging.
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Publication type Article: Journal article
Document type Review
Corresponding Author
Keywords Carbon Nanotubes; Molecular Fluorophores; Microscopy; Deep; Systems; Window; Donor; Brain; Dye
ISSN (print) / ISBN 1749-4885
e-ISSN 1749-4893
Journal Nature Photonics
Publisher Nature Publishing Group
Publishing Place Heidelberger Platz 3, Berlin, 14197, Germany
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Helmholtz Pioneer Campus (HPC)
Grants National Institutes of Health
U.S. Department of Health & Human Services | NIH | Center for Scientific Review (NIH Center for Scientific Review)