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Wiese, C.* ; Abele, M.* ; Al, B.* ; Altmann, M. ; Steiner, A.* ; Kalbfuß, N.* ; Strohmayr, A.* ; Ravikumar, R.* ; Park, C.H.* ; Brunschweiger, B.* ; Meng, C.* ; Facher, E.* ; Ehrhardt, D.W.* ; Falter-Braun, P. ; Wang, Z.Y.* ; Ludwig, C.* ; Assaad, F.F.*

Regulation of adaptive growth decisions via phosphorylation of the TRAPPII complex in Arabidopsis.

J. Cell Biol. 223:e202311125 (2024)
Publ. Version/Full Text DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
Plants often adapt to adverse or stress conditions via differential growth. The trans-Golgi network (TGN) has been implicated in stress responses, but it is not clear in what capacity it mediates adaptive growth decisions. In this study, we assess the role of the TGN in stress responses by exploring the previously identified interactome of the Transport Protein Particle II (TRAPPII) complex required for TGN structure and function. We identified physical and genetic interactions between AtTRAPPII and shaggy-like kinases (GSK3/AtSKs) and provided in vitro and in vivo evidence that the TRAPPII phosphostatus mediates adaptive responses to abiotic cues. AtSKs are multifunctional kinases that integrate a broad range of signals. Similarly, the AtTRAPPII interactome is vast and considerably enriched in signaling components. An AtSK-TRAPPII interaction would integrate all levels of cellular organization and instruct the TGN, a central and highly discriminate cellular hub, as to how to mobilize and allocate resources to optimize growth and survival under limiting or adverse conditions.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Trans-golgi-network; Multisubunit Tethering Complexes; Cell-wall Polysaccharides; Gene-expression; Computational Platform; Protein Phosphatases; Plasma-membrane; Cytokinesis; Trafficking; Quantification
ISSN (print) / ISBN 0021-9525
e-ISSN 1540-8140
Journal Journal of Cell Biology, The
Quellenangaben Volume: 223, Issue: 5, Pages: , Article Number: e202311125 Supplement: ,
Publisher Rockefeller University Press
Publishing Place 950 Third Ave, 2nd Flr, New York, Ny 10022 Usa
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Network Biology (INET)
Grants EU
National Institutes of Health
European Research Council
BaCa-TEC
Deutsche Forschungsgemeinschaft DFG