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Shmal, D.* ; Mantero, G.* ; Floss, T. ; Benfenati, F.* ; Maya-Vetencourt, J.F.*

Restoring vision in adult amblyopia by enhancing plasticity through deletion of the transcriptional repressor REST.

iScience 27:109507 (2024)

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Visual cortical plasticity is high during early life, but gradually decreases with development. This is due to the Otx2-driven maturation of intracortical inhibition that parallels the condensation of extracellular matrix components into perineuronal nets mainly around parvalbumin-positive GABAergic neurons. Repressor Element 1 Silencing Transcription (REST) epigenetically controls the expression of a plethora of neuron-specific genes. We demonstrate that the conditional knockout of REST in the primary visual cortex of adult mice induces a shift of ocular dominance after short-term monocular deprivation and promotes the recovery of vision in long-term deprived animals after reverse suture. These phenomena paralleled a reduction of perineuronal net density and increased expression of REST target genes, but not of the homeoprotein Otx2 in the visual cortex contralateral to the deprived eye. This shows that REST regulates adult visual cortical plasticity and is a potential therapeutic target to restore vision in adult amblyopia by enhancing V1 plasticity.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Biological Sciences ; Natural Sciences ; Neuroscience ; Sensory Neuroscience ; Systems Neuroscience; Ocular Dominance Plasticity; Visual-cortex; Critical-period; Monocular Deprivation; Regulates Plasticity; In-vivo; Expression; Recovery; Reactivation; Activation

ISSN (print) / ISBN 2589-0042

e-ISSN 2589-0042

Journal iScience

Quellenangaben Volume: 27, Issue: 4, Article Number: 109507

Publisher Elsevier

Publishing Place Amsterdam ; Bosten ; London ; New York ; Oxford ; Paris ; Philadelphia ; San Diego ; St. Louis

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Developmental Genetics (IDG)

Grants IRCCS Ospedale Policlinico San Martino
Compagnia di San Paolo Torino
Italian Ministry of University and Research