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Open Access Green as soon as Postprint is submitted to ZB.
Lifelong persistence of nuclear RNAs in the mouse brain.
Science 384, 53-59 (2024)
Genomic DNA that resides in the nuclei of mammalian neurons can be as old as the organism itself. The life span of nuclear RNAs, which are critical for proper chromatin architecture and transcription regulation, has not been determined in adult tissues. In this work, we identified and characterized nuclear RNAs that do not turn over for at least 2 years in a subset of postnatally born cells in the mouse brain. These long-lived RNAs were stably retained in nuclei in a neural cell type-specific manner and were required for the maintenance of heterochromatin. Thus, the life span of neural cells may depend on both the molecular longevity of DNA for the storage of genetic information and also the extreme stability of RNA for the functional organization of chromatin.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Messenger-rna; Neurogenesis; Transcription; Proteins; Reveals; Package
ISSN (print) / ISBN
0036-8075
e-ISSN
1095-9203
Journal
Science
Quellenangaben
Volume: 384,
Issue: 6691,
Pages: 53-59
Publisher
American Association for the Advancement of Science (AAAS)
Publishing Place
1200 New York Ave, Nw, Washington, Dc 20005 Usa
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute for Pancreatic Beta Cell Research (IPI)
Grants
Deutsche Forschungsgemeinschaft
Nomis Foundation
DZNE
European Research Council
Boehringer Ingelheim Foundation
Nomis Foundation
DZNE
European Research Council
Boehringer Ingelheim Foundation