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Mueller, T.T.* ; Pilartz, M.* ; Thakur, M.C.* ; LangHeinrich, T.* ; Luo, J.* ; Block, R.* ; Hoeflinger, J.K.L.* ; Meister, S.* ; Karaj, F.* ; Perez, L.G.* ; Öllinger, R.* ; Engleitner, T.* ; Thoss, J.* ; Voelkl, M.* ; Tersteeg, C.* ; Koedel, U.* ; Kohlmaier, A.Z.* ; Teupser, D.* ; Wygrecka, M.* ; Ye, H. ; Preissner, K.T.* ; Radbruch, H.* ; Elezkurtaj, S.* ; Mack, M.* ; von Hundelshausen, P.* ; Weber, C.* ; Massberg, S.* ; Schulz, C.* ; Rad, R.* ; Huber, S.* ; Ishikawa-Ankerhold, H.* ; Engelmann, B.*

Mutual regulation of CD4+ T cells and intravascular fibrin in infections.

Haematologica 109, 2487-2499 (2024)
Publ. Version/Full Text DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Innate myeloid cells especially neutrophils and their extracellular traps are known to promote intravascular coagulation and thrombosis formation in infections and various other conditions. Innate myeloid cell dependent fibrin formation can support systemic immunity while its dysregulation enhances the severity of infectious diseases. Less is known about the immune mechanisms preventing dysregulation of fibrin homeostasis in infection. During experimental systemic infections local fibrin deposits in the liver microcirculation cause rapid arrest of CD4+ T cells. Arrested T helper cells mostly represent Th17 cells that partially originate from the small intestine. Intravascular fibrin deposits activate mouse and human CD4+ T cells which can be mediated by direct fibrin - CD4+ T cell interactions. Activated CD4+ T cells suppress fibrin deposition and microvascular thrombosis by directly counteracting coagulation activation by neutrophils and classical monocytes. T cell activation, which is initially triggered by IL- 12p40- and MHC-II dependent mechanisms, enhances intravascular fibrinolysis via LFA-1. Moreover, CD4+ T cells disfavor the association of the fibrinolysis inhibitor TAFI with fibrin whereby fibrin deposition is increased by TAFI in the absence but not presence of T cells. In human infections thrombosis development is inversely related to microvascular levels of CD4+ T cells. Thus, fibrin promotes LFA-1 dependent T helper cell activation in infections which drives a negative feedback cycle that rapidly restricts intravascular fibrin and thrombosis development.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
ISSN (print) / ISBN 0390-6078
e-ISSN 1592-8721
Journal Haematologica - The Hematology Journal
Quellenangaben Volume: 109, Issue: 8, Pages: 2487-2499 Article Number: , Supplement: ,
Publisher Ferrata Storti Foundation
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Regenerative Biology (IRBM)