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The Obese Taste Bud study: Objectives and study design.
Diabetes Obes. Metab. 26, 2054-2068 (2024)
AimsTaste modifies eating behaviour, impacting body weight and potentially obesity development. The Obese Taste Bud (OTB) Study is a prospective cohort study launched in 2020 at the University of Leipzig Obesity Centre in cooperation with the HI-MAG Institute. OTB will test the hypothesis that taste cell homeostasis and taste perception are linked to obesity. Here, we provide the study design, data collection process and baseline characteristics.Materials and MethodsParticipants presenting overweight, obesity or normal weight undergo taste and smell tests, anthropometric, and taste bud density (TBD) assessment on Day 1. Information on physical and mental health, eating behaviour, physical activity, and dental hygiene are obtained, while biomaterial (saliva, tongue swap, blood) is collected in the fasted state. Further blood samples are taken during a glucose tolerance test. A stool sample is collected at home prior to Day 2, on which a taste bud biopsy follows dental examination. A subsample undergoes functional magnetic resonance imaging while exposed to eating-related cognitive tasks. Follow-up investigations after conventional weight loss interventions and bariatric surgery will be included.ResultsInitial results show that glycated haemoglobin levels and age are negatively associated with TBD, while an unfavourable metabolic profile, current dieting, and vegan diet are related to taste perception. Olfactory function negatively correlates with age and high-density lipoprotein cholesterol.ConclusionInitial findings suggest that metabolic alterations are relevant for taste and smell function and TBD. By combining omics data from collected biomaterial with physiological, metabolic and psychological data related to taste perception and eating behaviour, the OTB study aims to strengthen our understanding of taste perception in obesity.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
inflammation; metabolic disease; obesity; oral microbiome; taste cell homeostasis; taste perception; Age-related-changes; Food Cravings; Form; Questionnaire; Reliability; Thresholds; Perception; Density; Scale; Smell
ISSN (print) / ISBN
1462-8902
e-ISSN
1463-1326
Journal
Diabetes, Obesity and Metabolism
Quellenangaben
Volume: 26,
Issue: 6,
Pages: 2054-2068
Publisher
Wiley
Publishing Place
111 River St, Hoboken 07030-5774, Nj Usa
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Helmholtz Institute for Metabolism, Obesity and Vascular Research (HI-MAG)
Grants
Medical Faculty, University of Leipzig