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Carbone, J.* ; Bibián, C.* ; Born, J. ; Forcato, C.* ; Diekelmann, S.*

Comparing targeted memory reactivation during slow wave sleep and sleep stage 2.

Sci. Rep. 14:9057 (2024)
Publ. Version/Full Text DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Sleep facilitates declarative memory consolidation, which is assumed to rely on the reactivation of newly encoded memories orchestrated by the temporal interplay of slow oscillations (SO), fast spindles and ripples. SO as well as the number of spindles coupled to SO are more frequent during slow wave sleep (SWS) compared to lighter sleep stage 2 (S2). But, it is unclear whether memory reactivation is more effective during SWS than during S2. To test this question, we applied Targeted Memory Reactivation (TMR) in a declarative memory design by presenting learning-associated sound cues during SWS vs. S2 in a counterbalanced within-subject design. Contrary to our hypothesis, memory performance was not significantly better when cues were presented during SWS. Event-related potential (ERP) amplitudes were significantly higher for cues presented during SWS than S2, and the density of SO and SO-spindle complexes was generally higher during SWS than during S2. Whereas SO density increased during and after the TMR period, SO-spindle complexes decreased. None of the parameters were associated with memory performance. These findings suggest that the efficacy of TMR does not depend on whether it is administered during SWS or S2, despite differential processing of memory cues in these sleep stages.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Consolidation; Spindles; Oscillations; Increases; Stimulation; Vocabulary; Ripples; Waking; Brain
ISSN (print) / ISBN 2045-2322
e-ISSN 2045-2322
Journal Scientific Reports
Quellenangaben Volume: 14, Issue: 1, Pages: , Article Number: 9057 Supplement: ,
Publisher Nature Publishing Group
Publishing Place London
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes Research and Metabolic Diseases (IDM)
Grants Projekt DEAL
Bayesian statistics
University of Tubingen
Deutscher Akademischer Austauschdienst (DAAD)
CONICET/MINCyT
Deutsche Forschungsgemeinschaft (DFG)