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Khani, S.* ; Topel, H.* ; Kardinal, R.* ; Tavanez, A.R.* ; Josephrajan, A.* ; Larsen, B.D.M.* ; Gaudry, M.J.* ; Leyendecker, P.* ; Egedal, N.M.* ; Güller, A.S.* ; Stanic, N.* ; Ruppert, P.M.M.* ; Gaziano, I.* ; Hansmeier, N.R.* ; Schmidt, E.* ; Klemm, P.* ; Vagliano, L.M.* ; Stahl, R.* ; Duthie, F.* ; Krause, J.H.* ; Bici, A.* ; Engelhard, C.A.* ; Gohlke, S.* ; Frommolt, P.* ; Gnad, T.* ; Rada-Iglesias, A.* ; Pradas-Juni, M.* ; Schulz, T.J.* ; Wunderlich, F.T.* ; Pfeifer, A.* ; Bartelt, A. ; Jastroch, M.* ; Wachten, D.* ; Kornfeld, J.W.*

Cold-induced expression of a truncated adenylyl cyclase 3 acts as rheostat to brown fat function.

Nat. Metab., DOI: 10.1038/s42255-024-01033-8 (2024)
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Promoting brown adipose tissue (BAT) activity innovatively targets obesity and metabolic disease. While thermogenic activation of BAT is well understood, the rheostatic regulation of BAT to avoid excessive energy dissipation remains ill-defined. Here, we demonstrate that adenylyl cyclase 3 (AC3) is key for BAT function. We identified a cold-inducible promoter that generates a 5′ truncated AC3 mRNA isoform (Adcy3-at), whose expression is driven by a cold-induced, truncated isoform of PPARGC1A (PPARGC1A-AT). Male mice lacking Adcy3-at display increased energy expenditure and are resistant to obesity and ensuing metabolic imbalances. Mouse and human AC3-AT are retained in the endoplasmic reticulum, unable to translocate to the plasma membrane and lack enzymatic activity. AC3-AT interacts with AC3 and sequesters it in the endoplasmic reticulum, reducing the pool of adenylyl cyclases available for G-protein-mediated cAMP synthesis. Thus, AC3-AT acts as a cold-induced rheostat in BAT, limiting adverse consequences of cAMP activity during chronic BAT activation.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Adipose-tissue; Transcriptional Regulation; Gene; Obesity; Camp; Differentiation; Thermogenesis; Disruption; Metabolism; Activation
Language english
Publication Year 2024
HGF-reported in Year 2024
ISSN (print) / ISBN 2522-5812
e-ISSN 2522-5812
Journal Nature metabolism
Publisher Springer
Publishing Place London
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes and Cancer (IDC)
POF-Topic(s) 90000 - German Center for Diabetes Research
Research field(s) Helmholtz Diabetes Center
PSP Element(s) G-501900-251
Grants European Molecular Biology Organization (EMBO)
EC | EC Seventh Framework Programm | FP7 Ideas: European Research Council (FP7-IDEAS-ERC - Specific Programme: "Ideas" Implementing the Seventh Framework Programme of the European Community for Research, Technological Development and Demonstration Activit
Novo Nordisk Fonden (Novo Nordisk Foundation)
Deutscher Akademischer Austauschdienst (German Academic Exchange Service)
Deutsche Forschungsgemeinschaft (German Research Foundation)
DOI 10.1038/s42255-024-01033-8
WOS ID 001209548100001
Scopus ID 85191850631
PubMed ID 38684889
Erfassungsdatum 2024-05-23
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