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Achenbach, P. ; Berner, R.* ; Bonifacio, E.* ; Brämswig, S.* ; Braig, S.* ; Dunstheimer, D.* ; Ermer, U.* ; Ewald, D.* ; Gemulla, G.* ; Hauer, J.* ; Haupt, F. ; Haus, G.* ; Hubmann, M.* ; Hummel, S. ; Kandler, M.* ; Kordonouri, O.* ; Lange, K.* ; Laub, O.* ; Lorrmann, A.* ; Nellen-Hellmuth, N.* ; Sindichakis, M.* ; von dem Berge, T.* ; Warncke, K.* ; Weber, L.* ; Winkler, C. ; Wintermeyer, P.* ; Ziegler, A.-G.

Früherkennung von Typ-1-Diabetes durch Inselautoantikörper-Screening – ein Positionspapier der Fr1daPlex-Projektleiter und -Schulungszentren, des BVKJ Bayern und PaedNetz Bayern e.V.

Gesundheitswesen, DOI: 10.1055/a-2320-2859 (2024)
Publ. Version/Full Text DOI PMC
Open Access Hybrid
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This position paper is based on the authors' many years of clinical experience and basic science research on the diagnosis and treatment of children and adolescents with a presymptomatic early stage of type 1 diabetes. The benefits as well as potential disadvantages of early detection of type 1 diabetes by islet autoantibody screening are critically discussed. In addition, the perspectives of delaying the onset of the clinical metabolic disease through treatment with teplizumab are addressed. Today, we see the chance of a relevant improvement in the therapeutic options and life perspectives of affected children and adolescents. Important next steps for the implementation of islet autoantibody screening in Germany are the training of pediatricians who should inform families about the screening, the establishment of a few transregional laboratories that carry out the test, and the expansion of regional capacities for the training and care of children with an early stage of type 1 diabetes.
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Publication type Article: Journal article
Document type Position paper
Keywords type 1 diabetes; early detection in children; presymptomatic early stage; islet autoantibody screening; type 1 diabetes; early detection in children; presymptomatic early stage; islet autoantibody screening; C-peptide Responses; Beta-cell Function; New-onset; Clinical Characteristics; Young-adults; Children; Ketoacidosis; Risk; Complications; Progression
Language german
Publication Year 2024
HGF-reported in Year 2024
ISSN (print) / ISBN 0941-3790
e-ISSN 1439-4421
Journal Gesundheitswesen, Das
Publisher Thieme
Publishing Place Rudigerstr 14, D-70469 Stuttgart, Germany
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes Research (IDF)
POF-Topic(s) 30201 - Metabolic Health
90000 - German Center for Diabetes Research
Research field(s) Helmholtz Diabetes Center
PSP Element(s) G-502100-001
G-501900-211
DOI 10.1055/a-2320-2859
WOS ID 001280124900001
Scopus ID 85193536922
PubMed ID 38710228
Erfassungsdatum 2024-06-11
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