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Hopff, S.M.* ; Appel, K.S.* ; Miljukov, O.* ; Schneider, J.* ; Addo, M.M.* ; Bals, R.* ; Bercker, S.* ; Blaschke, S.* ; Bröhl, I.* ; Büchner, N.* ; Dashti, H.S.* ; Erber, J.* ; Friedrichs, A.* ; Geisler, R.* ; Göpel, S.* ; Hagen, M.* ; Hanses, F.* ; Jensen, B.O.* ; Keul, M.* ; Krawczyk, A.* ; Lorenz-Depiereux, B. ; Meybohm, P.* ; Milovanovic, M.* ; Mitrov, L.* ; Nürnberger, C.* ; Obst, W.* ; Römmele, C.* ; Schäfer, C.* ; Scheer, C.E.* ; Scherer, M.* ; Schmidt, J.* ; Seibel, K.* ; Sikdar, S.* ; Tebbe, J.J.* ; Tepasse, P.R.* ; Thelen, P.* ; Vehreschild, M.J.G.T.* ; Weismantel, C.* ; Vehreschild, J.J.*

Comparison of post-COVID-19 symptoms in patients infected with the SARS-CoV-2 variants delta and omicron-results of the Cross-Sectoral Platform of the German National Pandemic Cohort Network (NAPKON-SUEP).

Infection, DOI: 10.1007/s15010-024-02270-5 (2024)
DOI PMC
Creative Commons Lizenzvertrag
PURPOSE: The influence of new SARS-CoV-2 variants on the post-COVID-19 condition (PCC) remains unanswered. Therefore, we examined the prevalence and predictors of PCC-related symptoms in patients infected with the SARS-CoV-2 variants delta or omicron. METHODS: We compared prevalences and risk factors of acute and PCC-related symptoms three months after primary infection (3MFU) between delta- and omicron-infected patients from the Cross-Sectoral Platform of the German National Pandemic Cohort Network. Health-related quality of life (HrQoL) was determined by the EQ-5D-5L index score and trend groups were calculated to describe changes of HrQoL between different time points. RESULTS: We considered 758 patients for our analysis (delta: n = 341; omicron: n = 417). Compared with omicron patients, delta patients had a similar prevalence of PCC at the 3MFU (p = 0.354), whereby fatigue occurred most frequently (n = 256, 34%). HrQoL was comparable between the groups with the lowest EQ-5D-5L index score (0.75, 95% CI 0.73-0.78) at disease onset. While most patients (69%, n = 348) never showed a declined HrQoL, it deteriorated substantially in 37 patients (7%) from the acute phase to the 3MFU of which 27 were infected with omicron. CONCLUSION: With quality-controlled data from a multicenter cohort, we showed that PCC is an equally common challenge for patients infected with the SARS-CoV-2 variants delta and omicron at least for the German population. Developing the EQ-5D-5L index score trend groups showed that over two thirds of patients did not experience any restrictions in their HrQoL due to or after the SARS-CoV-2 infection at the 3MFU. CLINICAL TRAIL REGISTRATION: The cohort is registered at ClinicalTrials.gov since February 24, 2021 (Identifier: NCT04768998).
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Health-related Quality Of Life ; Multicenter Prospective Cohort Study ; Post-covid-19 Condition ; Sars-cov-2 Variants; South-africa; Population; Outcomes
ISSN (print) / ISBN 0300-8126
e-ISSN 1439-0973
Journal Infection - A Journal of Infectious Disease
Publisher Urban & Vogel
Publishing Place Tiergartenstrasse 17, D-69121 Heidelberg, Germany
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology II (EPI2)
Grants German Center for Infection Research (DZIF)
Bavarian Ministry of Research and Art
German Federal Ministry of Education and Research (BMBF)
Projekt DEAL