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Open Access Gold as soon as Publ. Version/Full Text is submitted to ZB.
Genetic polymorphisms affecting telomere length and their association with cardiovascular disease in the Heinz-Nixdorf-Recall study.
PLoS ONE 19:e0303357 (2024)
Short telomeres are associated with cardiovascular disease (CVD). We aimed to investigate, if genetically determined telomere-length effects CVD-risk in the Heinz-Nixdorf-Recall study (HNRS) population. We selected 14 single-nucleotide polymorphisms (SNPs) associated with telomere-length (p<10-8) from the literature and after exclusion 9 SNPs were included in the analyses. Additionally, a genetic risk score (GRS) using these 9 SNPs was calculated. Incident CVD was defined as fatal and non-fatal myocardial infarction, stroke, and coronary death. We included 3874 HNRS participants with available genetic data and had no known history of CVD at baseline. Cox proportional-hazards regression was used to test the association between the SNPs/GRS and incident CVD-risk adjusting for common CVD risk-factors. The analyses were further stratified by CVD risk-factors. During follow-up (12.1±4.31 years), 466 participants experienced CVD-events. No association between SNPs/GRS and CVD was observed in the adjusted analyses. However, the GRS, rs10936599, rs2487999 and rs8105767 increase the CVD-risk in current smoker. Few SNPs (rs10936599, rs2487999, and rs7675998) showed an increased CVD-risk, whereas rs10936599, rs677228 and rs4387287 a decreased CVD-risk, in further strata. The results of our study suggest different effects of SNPs/GRS on CVD-risk depending on the CVD risk-factor strata, highlighting the importance of stratified analyses in CVD risk-factors.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Coronary-artery Calcification; C-reactive Protein; Risk-factors; Common Variants; Cigarette-smoking; Blood-pressure; Heart-disease; Hypertension; Atherosclerosis; Quantification
ISSN (print) / ISBN
1932-6203
Journal
PLoS ONE
Quellenangaben
Volume: 19,
Issue: 5,
Article Number: e0303357
Publisher
Public Library of Science (PLoS)
Publishing Place
Lawrence, Kan.
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Asthma and Allergy Prevention (IAP)
Grants
Open Access Publication Fund of the University of Duisburg-Essen
Sarstedt AG & Co. (Numbrecht, Germany)
GE Imatron Inc., South San Francisco, CA
Ministry of Innovation, Science and Research, Nordrhine-Westfalia
Bundesministerium fur Bildung und Forschung
Deutsche Forschungsgemeinschaft
Heinz Nixdorf Foundation
Sarstedt AG & Co. (Numbrecht, Germany)
GE Imatron Inc., South San Francisco, CA
Ministry of Innovation, Science and Research, Nordrhine-Westfalia
Bundesministerium fur Bildung und Forschung
Deutsche Forschungsgemeinschaft
Heinz Nixdorf Foundation