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Ester-Nacke, T. ; Berti, K. ; Veit, R. ; Dannecker, C. ; Salvador, R.* ; Ruffini, G.* ; Heni, M. ; Birkenfeld, A.L. ; Plewnia, C.* ; Preissl, H. ; Kullmann, S.

Network-targeted transcranial direct current stimulation of the hypothalamus appetite-control network: A feasibility study.

Sci. Rep. 14:11341 (2024)
Publ. Version/Full Text DOI PMC
Open Access Gold
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The hypothalamus is the key regulator for energy homeostasis and is functionally connected to striatal and cortical regions vital for the inhibitory control of appetite. Hence, the ability to non-invasively modulate the hypothalamus network could open new ways for the treatment of metabolic diseases. Here, we tested a novel method for network-targeted transcranial direct current stimulation (net-tDCS) to influence the excitability of brain regions involved in the control of appetite. Based on the resting-state functional connectivity map of the hypothalamus, a 12-channel net-tDCS protocol was generated (Neuroelectrics Starstim system), which included anodal, cathodal and sham stimulation. Ten participants with overweight or obesity were enrolled in a sham-controlled, crossover study. During stimulation or sham control, participants completed a stop-signal task to measure inhibitory control. Overall, stimulation was well tolerated. Anodal net-tDCS resulted in faster stop signal reaction time (SSRT) compared to sham (p = 0.039) and cathodal net-tDCS (p = 0.042). Baseline functional connectivity of the target network correlated with SSRT after anodal compared to sham stimulation (p = 0.016). These preliminary data indicate that modulating hypothalamus functional network connectivity via net-tDCS may result in improved inhibitory control. Further studies need to evaluate the effects on eating behavior and metabolism.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords State Functional Connectivity; Cognitive Control; Inhibitory Control; Brain; Tdcs; Excitability; Metaanalysis; Responses; Weight; Cortex
ISSN (print) / ISBN 2045-2322
e-ISSN 2045-2322
Journal Scientific Reports
Quellenangaben Volume: 14, Issue: 1, Pages: , Article Number: 11341 Supplement: ,
Publisher Nature Publishing Group
Publishing Place London
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes Research and Metabolic Diseases (IDM)
Grants Projekt DEAL
Federal Ministry of Education and Research (BMBF)