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Open Access Green as soon as Postprint is submitted to ZB.
Beyond CAR T cells: exploring alternative cell sources for CAR-like cellular therapies.
Biol. Chem., DOI: 10.1515/hsz-2023-0317 (2024)
Chimeric antigen receptor (CAR)-T cell therapy has led to remarkable clinical outcomes in the treatment of hematological malignancies. However, challenges remain, such as limited infiltration into solid tumors, inadequate persistence, systemic toxicities, and manufacturing insufficiencies. The use of alternative cell sources for CAR-based therapies, such as natural killer cells (NK), macrophages (MΦ), invariant Natural Killer T (iNKT) cells, γδT cells, neutrophils, and induced pluripotent stem cells (iPSC), has emerged as a promising avenue. By harnessing these cells' inherent cytotoxic mechanisms and incorporating CAR technology, common CAR-T cell-related limitations can be effectively mitigated. We herein present an overview of the tumoricidal mechanisms, CAR designs, and manufacturing processes of CAR-NK cells, CAR-MΦ, CAR-iNKT cells, CAR-γδT cells, CAR-neutrophils, and iPSC-derived CAR-cells, outlining the advantages, limitations, and potential solutions of these therapeutic strategies.
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Publication type
Article: Journal article
Document type
Review
Keywords
Car-nk Cells ; Car-t Cells ; Car-inkt Cells ; Car-macrophages ; Car-neutrophils ; Car-γδt cells; Chimeric-antigen-receptor; Natural-killer-cells; Pluripotent Stem-cells; V-alpha-24-invariant Nkt Cells; Acute Myeloid-leukemia; In-vivo Expansion; Phase-i; Dendritic Cells; Adoptive Immunotherapy; Antitumor-activity
ISSN (print) / ISBN
1431-6730
e-ISSN
1437-4315
Journal
Biological Chemistry
Publisher
de Gruyter
Publishing Place
Genthiner Strasse 13, D-10785 Berlin, Germany
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Unit for Clinical Pharmacology (KKG-EKLiP)
Grants
Go-Bio-Initiative