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Vecellio Reane, D. ; Serna, J.D.C.* ; Raffaello, A.*

Unravelling the complexity of the mitochondrial Ca2+ uniporter: Regulation, tissue specificity, and physiological implications.

Cell Calcium 121:102907 (2024)
Publ. Version/Full Text DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
Calcium (Ca2+) signalling acts a pleiotropic message within the cell that is decoded by the mitochondria through a sophisticated ion channel known as the Mitochondrial Ca2+ Uniporter (MCU) complex. Under physiological conditions, mitochondrial Ca2+ signalling is crucial for coordinating cell activation with energy production. Conversely, in pathological scenarios, it can determine the fine balance between cell survival and death. Over the last decade, significant progress has been made in understanding the molecular bases of mitochondrial Ca2+ signalling. This began with the elucidation of the MCU channel components and extended to the elucidation of the mechanisms that regulate its activity. Additionally, increasing evidence suggests molecular mechanisms allowing tissue-specific modulation of the MCU complex, tailoring channel activity to the specific needs of different tissues or cell types. This review aims to explore the latest evidence elucidating the regulation of the MCU complex, the molecular factors controlling the tissue-specific properties of the channel, and the physiological and pathological implications of mitochondrial Ca2+ signalling in different tissues.
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Publication type Article: Journal article
Document type Review
Corresponding Author
Keywords Brain ; Calcium Signalling ; Heart ; Liver ; Mcu Regulation ; Mitochondrial Calcium Uniporter ; Skeletal Muscle ; Tissue-specific Modulation; Calcium Uniporter; Mice Lacking; Metabolic Flexibility; Essential Component; Stress Responses; Cyclosporine-a; Mcu; Mechanisms; Channel; Homeostasis
ISSN (print) / ISBN 0143-4160
e-ISSN 1532-1991
Journal Cell calcium
Quellenangaben Volume: 121, Issue: , Pages: , Article Number: 102907 Supplement: ,
Publisher Elsevier
Publishing Place Amsterdam
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes and Obesity (IDO)
Grants Euro-pean Union (Next-Generation)
European Union