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Karampelias, C. ; Lickert, H.

Greasing the machinery toward maturation of stem cell-derived β cells.

Cell Stem Cell 31, 793-794 (2024)

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Getting mature and functional stem cell-derived, insulin-producing β cells is an important step for disease modeling, drug screening, and cell replacement therapy. In this issue, Hua et al.1 used single-cell multiomics analysis coupled with chemical screening to identify a crucial role for ceramides in generating mature stem cell-derived β cells.

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