PuSH - Publication Server of Helmholtz Zentrum München: Mitochondrial lipidomes are tissue specific - low cholesterol contents relate to UCP1 activity.

Information

Clues to quality of journals

Open Access Policy of Helmholtz Association 2016

CC Licencences

Publication Metrics

Navigation

Home

Deutsch

EVA: Electronic Publishing

New EVA Application

Research

Advanced Search

Browse by ...

... HMGU-Authors/Consortia

... Organizational Structure

... Journal

... Publication Type

... Research Data

... Arbeitsgruppen

... Publication Year

Publication overview

Statistics

Statistics (last 5 years)

OA Publications

Publish

Submit Publication

Import publication from...

...EVA

Report missing publication

Highlights

Support & Contact

Contact persons

Help

Data protection

Helmholtz Open Science

JANE Journal Estimator

SHERPA/RoMEO

DOAJ

Export:

Text

Endnote (RIS) BIB

BibTeX

Brunner, S.* ; Höring, M.* ; Liebisch, G.* ; Schweizer, S.* ; Scheiber, J.* ; Giansanti, P.* ; Hidrobo, M.S.* ; Hermeling, S.* ; Oeckl, J.* ; Prudente de Mello, N. ; Perocchi, F. ; Seeliger, C.* ; Strohmeyer, A.* ; Klingenspor, M.* ; Plagge, J.* ; Küster, B.* ; Burkhardt, R.* ; Janssen, K.P.* ; Ecker, J.*

Mitochondrial lipidomes are tissue specific - low cholesterol contents relate to UCP1 activity.

Life Sci. All. 7:e202402828 (2024)

Publ. Version/Full Text

DOI

PMC

	Open Access Gold

Abstract
Metrics
Extra information

Lipid composition is conserved within sub-cellular compartments to maintain cell function. Lipidomic analyses of liver, muscle, white and brown adipose tissue (BAT) mitochondria revealed substantial differences in their glycerophospholipid (GPL) and free cholesterol (FC) contents. The GPL to FC ratio was 50-fold higher in brown than white adipose tissue mitochondria. Their purity was verified by comparison of proteomes with ER and mitochondria-associated membranes. A lipid signature containing PC and FC, calculated from the lipidomic profiles, allowed differentiation of mitochondria from BAT of mice housed at different temperatures. Elevating FC in BAT mitochondria prevented uncoupling protein (UCP) 1 function, whereas increasing GPL boosted it. Similarly, STARD3 overexpression facilitating mitochondrial FC import inhibited UCP1 function in primary brown adipocytes, whereas a knockdown promoted it. We conclude that the mitochondrial GPL/FC ratio is key for BAT function and propose that targeting it might be a promising strategy to promote UCP1 activity.

Impact Factor

Scopus SNIP

Altmetric

3.300

0.000