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Nakamura, T. ; Conrad, M.

Exploiting ferroptosis vulnerabilities in cancer.

Nat. Cell Biol., DOI: 10.1038/s41556-024-01425-8 (2024)
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Ferroptosis is a distinct lipid peroxidation-dependent form of necrotic cell death. This process has been increasingly contemplated as a new target for cancer therapy because of an intrinsic or acquired ferroptosis vulnerability in difficult-to-treat cancers and tumour microenvironments. Here we review recent advances in our understanding of the molecular mechanisms that underlie ferroptosis and highlight available tools for the modulation of ferroptosis sensitivity in cancer cells and communication with immune cells within the tumour microenvironment. We further discuss how these new insights into ferroptosis-activating pathways can become new armouries in the fight against cancer.
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Publication type Article: Journal article
Document type Review
Keywords Cell-death; T-cells; Glutathione Synthesis; Lipid-peroxidation; Oxidative Stress; Gpx4; Inhibition; Selenium; Suppressor; Growth
Language english
Publication Year 2024
HGF-reported in Year 2024
ISSN (print) / ISBN 1465-7392
e-ISSN 1476-4679
Journal Nature Cell Biology
Publisher Nature Publishing Group
Publishing Place Heidelberger Platz 3, Berlin, 14197, Germany
Reviewing status Peer reviewed
Institute(s) Institute of Metabolism and Cell Death (MCD)
POF-Topic(s) 30203 - Molecular Targets and Therapies
Research field(s) Genetics and Epidemiology
PSP Element(s) G-506900-001
Grants European Research Council (ERC) under the European Union
EC | EC Seventh Framework Programm | FP7 Ideas: European Research Council (FP7-IDEAS-ERC - Specific Programme: "Ideas" Implementing the Seventh Framework Programme of the European Community for Research, Technological Development and Demonstration Activit
Deutsche Forschungsgemeinschaft (DFG)
CRC TRR 353
German Federal Ministry of Education and Research (BMBF) FERROPATH
DOI 10.1038/s41556-024-01425-8
WOS ID 001242786700002
Scopus ID 85195446941
PubMed ID 38858502
Erfassungsdatum 2024-06-12
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