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Correlating maternal and cord-blood inflammatory markers and BDNF with human fetal brain activity recorded by magnetoencephalography: An exploratory study.
Brain Behav. Immun. 52, 399-405 (2024)
Background: During gestation, the brain development of the fetus is affected by many biological markers, where inflammatory processes and neurotrophic factors have been of particular interest in the past decade. Aim: This exploratory study is the first attempt to explore the relationships between biomarker levels in maternal and cord-blood samples and human fetal brain activity measured with non-invasive fetal magnetoencephalography (fMEG). Method: Twenty-three women were enrolled in this study for collection of maternal serum and fMEG tracings immediately prior to their scheduled cesarean delivery. Twelve of these women had a preexisting diabetic condition. At the time of delivery, umbilical cord blood was also collected. Biomarker levels from both maternal and cord blood were measured and subsequently analyzed for correlations with fetal brain activity in four frequency bands extracted from fMEG power spectral densities. Results: Relative power in the delta, alpha, and beta frequency bands exhibited moderate-sized correlations with maternal BDNF and cord-blood CRP levels before and after adjusting for confounding diabetic status. These correlations were negative for the delta band, and positive for the alpha and beta bands. Maternal CRP and cord-blood BDNF and IL-6 exhibited negligible correlations with relative power in all four bands. Diabetes did not appear to be a strong confounding factor affecting the studied biomarkers. Conclusions: Maternal BDNF levels and cord-blood CRP levels appear to have a direct correlation to fetal brain activity. Our findings indicate the potential use of these biomarkers in conjunction with fetal brain electrophysiology to track fetal neurodevelopment.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Bdnf ; Brain-derived Neurotrophic Factor ; Fetal Brain Activity ; Il-6 ; Inflammatory Markers ; Relative Power; C-reactive Protein; Neurotrophic Factor Bdnf; Umbilical-cord; Children Born; Pregnancy; Connectivity; Postpartum; Activation; Cytokines; Patterns
ISSN (print) / ISBN
0889-1591
e-ISSN
1090-2139
Journal
Brain, Behavior and Immunity
Quellenangaben
Volume: 52,
Issue: 4,
Pages: 399-405
Publisher
Elsevier
Publishing Place
Amsterdam [u.a.]
Non-patent literature
Publications
Reviewing status
Peer reviewed
Grants
National Institutes of Health - NICHD
Sturgis Foundation for Diabetes Research, UAMS College of Medicine, Office of Research Intramural Grant Program
Sturgis Foundation for Diabetes Research, UAMS College of Medicine, Office of Research Intramural Grant Program