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Couacault, P. ; Avella, D.* ; Londoño-Osorio, S.* ; Lorenzo, A.S.* ; Gradillas, A.* ; Kärkkäinen, O.* ; Want, E.* ; Witting, M.

Targeted and untargeted metabolomics and lipidomics in dried blood microsampling: Recent applications and perspectives.

Anal. Sci. Adv. 5:e2400002 (2024)

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Blood microsampling (BµS) offers an alternative to conventional methods that use plasma or serum for profiling human health, being minimally invasive and cost effective, especially beneficial for vulnerable populations. We present a non-systematic review that offers a synopsis of the analytical methods, applications and perspectives related to dry blood microsampling in targeted and untargeted metabolomics and lipidomics research in the years 2022 and 2023. BµS shows potential in neonatal and paediatric studies, therapeutic drug monitoring, metabolite screening, biomarker research, sports supervision, clinical disorders studies and forensic toxicology. Notably, dried blood spots and volumetric absorptive microsampling options have been more extensively studied than other volumetric technologies. Therefore, we suggest that a further investigation and application of the volumetric technologies will contribute to the use of BµS as an alternative to conventional methods. Conversely, we support the idea that harmonisation of the analytical methods when using BµS would have a positive impact on its implementation.

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Publication type Article: Journal article

Document type Review

Corresponding Author

Keywords Blood Microsampling ; Dried Blood ; Lc–ms Analysis ; Lipidomics ; Metabolomics ; Targeted And Untargeted; Spots

ISSN (print) / ISBN 2628-5452

e-ISSN 2628-5452

Journal Analytical Science Advances

Quellenangaben Volume: 5, Issue: 5-6, Article Number: e2400002

Publisher Wiley

Publishing Place 111 River St, Hoboken 07030-5774, Nj Usa

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) CF Metabolomics & Proteomics (CF-MPC)

Grants Marie Curie Actions
European Union
HORIZON EUROPE Marie Sklodowska-Curie Actions