PuSH - Publication Server of Helmholtz Zentrum München: SGLT2 inhibitors correct fluid overload in adult kidney transplant recipients-A prospective observational study.

Navigation

Home

Deutsch

Research

Advanced Search

Browse by ...

... Journal

... Publication Type

... Research Data

... Publication Year

Publication overview

Support & Contact

Contact persons

Help

Data protection

Schork, A. ; Eberbach, M.-L. ; Artunc, F. ; Bohnert, B.N. ; Eisinger, F. ; Heister, D.J. ; Vosseler, A. ; Nadalin, S.* ; Birkenfeld, A.L. ; Heyne, N. ; Guthoff, M.

SGLT2 inhibitors correct fluid overload in adult kidney transplant recipients-A prospective observational study.

Transpl. Int. 37:12879 (2024)

Publ. Version/Full Text

DOI

PMC

	Open Access Gold (Paid Option)

Abstract
Metrics
Extra information

In this longitudinal observational study, we measured urinary glucose concentration, body composition and volume status (bioimpedance spectroscopy) and plasma renin and aldosterone concentrations in n = 22 kidney transplant recipients (KTRs) initiating on SGLT2I at baseline (BL), and after 1 week and 1, 3, and 6 months. Estimated glomerular filtration rate (eGFR) decreased by -2 mL/min/1.73 m² (IQR -10-0) after 1 week and remained stable thereafter. Urinary glucose concentration was 10 (3-24) g/g creatinine after 1 week and correlated with eGFR (r² = 0.273; p = 0.057). SGLT2I did not affect HbA1c, fasting blood glucose, body weight, fat or lean mass. SGLT2I decreased fluid overload dependent on baseline overhydration (OH, r² = 0.54, p = 0.0003) without occurrence of dehydration. Plasma aldosterone increased at day 7, while plasma renin did not change significantly. In conclusion, SGLT2I corrected fluid overload in patients with elevated overhydration at baseline, while in euvolemic KTRs fluid status remained stable without reduction of body water below the reference range, thus promoting the safety of SGLT2I therapy in patients following kidney transplantation. Glucosuria, together with effects of SGLT2I on blood glucose control and body weight, is attenuated in KTRs dependent on eGFR.

Altmetric

Additional Metrics?

[➜Log in]

Edit extra informations Login

Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Sglt2 Inhibitor ; Bioimpedance Spectroscopy ; Fluid Overload ; Glucosuria ; Kidney Transplantation

ISSN (print) / ISBN 0934-0874

e-ISSN 1432-2277

Journal Transplant international

Quellenangaben Volume: 37, Article Number: 12879

Publisher Wiley

Publishing Place Oxford

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Diabetes Research and Metabolic Diseases (IDM)