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Askani, E.* ; Rospleszcz, S. ; Lorbeer, R.* ; Wintergerst, C.* ; Müller-Peltzer, K.* ; Nattenmüller, J.* ; Hasic, D.* ; von Krüchten, R.* ; Kellner, E.* ; Reisert, M.* ; Rathmann, W.* ; Peters, A. ; Schlett, C.L.* ; Bamberg, F.* ; Storz, C.*

MRI-based adrenal gland volume is associated with cardiovascular alterations in individuals without prior cardiovascular disease.

Sci. Rep. 14:14664 (2024)
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Aim of this study was to analyse the associations of cardiovascular health and adrenal gland volume as a rather new imaging biomarker of chronic hypothalamic-pituitary-adrenal (HPA) axis activation. The study population originates from the KORA population-based cross-sectional prospective cohort. 400 participants without known cardiovascular disease underwent a whole-body MRI. Manual segmentation of adrenal glands was performed on VIBE-Dixon gradient-echo sequence. MRI based evaluation of cardiac parameters was achieved semi-automatically. Cardiometabolic risk factors were obtained through standardized interviews and medical examination. Univariate and multivariate associations were derived. Bi-directional causal mediation analysis was performed. 351 participants were eligible for analysis (56 ± 9.1 years, male 58.7%). In multivariate analysis, significant associations were observed between adrenal gland volume and hypertension (outcome hypertension: Odds Ratio = 1.11, 95% CI [1.01, 1.21], p = 0.028), left ventricular remodelling index (LVRI) (outcome LVRI: β = 0.01, 95% CI [0.00, 0.02], p = 0.011), and left ventricular (LV) wall thickness (outcome LV wall thickness: β = 0.06, 95% CI [0.02, 0.09], p = 0.005). In bi-directional causal mediation analysis adrenal gland volume had a borderline significant mediating effect on the association between hypertension and LVRI (p = 0.052) as well as wall thickness (p = 0.054). MRI-based assessment of adrenal gland enlargement is associated with hypertension and LV remodelling. Adrenal gland volume may serve as an indirect cardiovascular imaging biomarker.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Myocardial-infarction; Hair Cortisol; Glucocorticoids; Population; Kora
Language english
Publication Year 2024
HGF-reported in Year 2024
ISSN (print) / ISBN 2045-2322
e-ISSN 2045-2322
Journal Scientific Reports
Quellenangaben Volume: 14, Issue: 1, Pages: , Article Number: 14664 Supplement: ,
Publisher Nature Publishing Group
Publishing Place London
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
POF-Topic(s) 30202 - Environmental Health
Research field(s) Genetics and Epidemiology
PSP Element(s) G-504000-010
G-504090-001
Grants German Center for Diabetes Research (DZD e.V., Neuherberg, Germany)
German Center for Cardiovascular Disease Research (DZHK, Berlin, Germany)
German Research Foundation (DFG, Bonn, Germany)
State of Bavaria
German Federal Ministry of Education and Research (BMBF)
Helmholtz Zentrum Munchen - German Research Center for Environmental Health
Projekt DEAL
DOI 10.1038/s41598-024-65673-2
WOS ID 001255006800064
Scopus ID 85196844373
PubMed ID 38918570
Erfassungsdatum 2024-06-27
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