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Impaired skin barrier and allergic sensitization in 16-year-old adolescents.
Mon.schr. Kinderheilkd. 173, 217-225 (2024)
Background: Transepidermal water loss (TEWL) has been used to measure skin barrier function and has been associated with atopic dermatitis and allergic diseases in infancy. However, few studies have assessed the association between TEWL and allergic diseases in adolescents. Objective: To investigate the association between TEWL and allergic sensitizations in 16-year-old adolescents. Materials and methods: The study was conducted in 78 adolescents of the PASTURE study. Different types of sensitization (seasonal, perennial, inhalant, food and any) were defined using serum specific immunoglobulin E (IgE) and skin prick test. TEWL was measured on the crook of either right or the left arm using a TEWAMETER® TM 300 (Courage + Khazaka electronic, Cologne, Germany) at mean temperature and humidity of 24.1 °C and 36.1%, respectively. The mean TEWL and interquartile range (IQR) were 11.9 ± 4.4 and 4.8 g/m2/h respectively. Results: In our study, TEWL was positively associated with any sensitization (adjusted odds ratio [OR] per-IQR of the probability of increased TEWL [95% confidence interval]: OR 2.64; [1.12–6.19]; p = 0.03) and allergic rhinoconjunctivitis (ARC; OR 1.92; [1.04–3.54]; p = 0.04), but not with asthma or atopic dermatitis. When separating any sensitization into perennial and seasonal, only perennial sensitization (OR 3.30; [1.42–7.43]; p = 0.005) was associated with TEWL. Conclusion: In the present study, we show the association of defective skin barrier function measured as TEWL with perennial sensitization and ARC suggesting its possible role in the pathogenesis of ARC through sensitization.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Adolescence ; Allergic Rhinoconjunctivitis ; Allergic Sensitization ; Perennial Sensitization ; Transepidermal Water Loss; Children; Infants; Atopy; Age
ISSN (print) / ISBN
0026-9298
e-ISSN
1433-0474
Journal
Monatsschrift Kinderheilkunde
Quellenangaben
Volume: 173,
Issue: 3,
Pages: 217-225
Publisher
Springer
Publishing Place
One New York Plaza, Suite 4600, New York, Ny, United States
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Asthma and Allergy Prevention (IAP)
Grants
Deutsche Forschungsgemeinschaft (DFG)
Universities Giessen and Marburg Lung Center (UGMLC)
German Center for Lung Research (DZL)
University Hospital Giessen and Marburg (UKGM)
Forschungsgemeinschaft (DFG, German Research Foundation)
Foundation for Pathobiochemistry and Molecular Diagnostics
European Commission
Universities Giessen and Marburg Lung Center (UGMLC)
German Center for Lung Research (DZL)
University Hospital Giessen and Marburg (UKGM)
Forschungsgemeinschaft (DFG, German Research Foundation)
Foundation for Pathobiochemistry and Molecular Diagnostics
European Commission