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Diurnal rythm of Nampt is gender and weight dependent.
Obes. Res. Clin. Pract. 18, 181-188 (2024)
RESEARCH AIM: Nicotinamide phosphoribosyltransferase (Nampt) is an adipocytokine that is elevated in obesity, type 2 diabetes and increased levels are associated with inflammatory processes. Nampt serum concentrations have been suggested to follow a diurnal rhythm peaking in the afternoon in lean males. However, no data exists regarding the effects of gender and body weight. MATERIAL AND METHODS: We measured Nampt serum levels over 24 h in a cohort of healthy individuals living with either normal weight or obesity. Furthermore, effects of meals, oral glucose tolerance test and physical exercise on Nampt concentrations were evaluated. Correlation analyses to other hormonal- and lab parameters and anthropometric measurements were performed. RESULTS: Nampt showed a diurnal rhythm with increased levels at daytime and a peak in the early afternoon. This diurnal rhythm was significant for all groups but obese males. The Nampt amplitude, measured both relatively and absolutely, was significantly higher in females than in males. Meals did not influence Nampt serum levels, whereas physical exercise and an OGTT did significantly influence Nampt serum levels. CONCLUSION: In conclusion, we found gender specific differences in Nampt amplitude and coefficient variation with both being higher in females. The circadian rhythm of Nampt was independent of gender in healthy lean individuals, whereas it was disturbed in men with obesity.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Diurnal Rhythm ; Nampt ; Obesity; Plasma Visfatin Concentrations; Adipokine; Glucose; Obese; Fat
ISSN (print) / ISBN
1871-403X
e-ISSN
1878-0318
Quellenangaben
Volume: 18,
Issue: 3,
Pages: 181-188
Publisher
Elsevier
Publishing Place
125 London Wall, London, England
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Helmholtz Institute for Metabolism, Obesity and Vascular Research (HI-MAG)
Grants
Integrated Research and Treatment Centre (IFB) Adiposity Diseases
Federal Ministry of Education and Research (BMBF) , Germany
European Regional Development Fund (ERFD) by means of the Free State of Saxony
LIFE (Leipzig Research Center for Civilization Diseases, Universitat Leipzig) - European Union
German Research Foundation (DFG)
Federal Ministry of Education and Research (BMBF) , Germany
European Regional Development Fund (ERFD) by means of the Free State of Saxony
LIFE (Leipzig Research Center for Civilization Diseases, Universitat Leipzig) - European Union
German Research Foundation (DFG)