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Sailer, J.* ; Nagel, J.* ; Akdogan, B. ; Jauch, A.T.* ; Engler, J.B.* ; Knolle, P.A.* ; Zischka, H.

Deadly excess copper.

Redox Biol. 75:103256 (2024)
Publ. Version/Full Text DOI PMC
Open Access Gold
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Higher eukaryotes' life is impossible without copper redox activity and, literally, every breath we take biochemically demonstrates this. However, this dependence comes at a considerable price to ensure target-oriented copper action. Thereto its uptake, distribution but also excretion are executed by specialized proteins with high affinity for the transition metal. Consequently, malfunction of copper enzymes/transporters, as is the case in hereditary Wilson disease that affects the intracellular copper transporter ATP7B, comes with serious cellular damage. One hallmark of this disease is the progressive copper accumulation, primarily in liver but also brain that becomes deadly if left untreated. Such excess copper toxicity may also result from accidental ingestion or attempted suicide. Recent research has shed new light into the cell-toxic mechanisms and primarily affected intracellular targets and processes of such excess copper that may even be exploited with respect to cancer therapy. Moreover, new therapies are currently under development to fight against deadly toxic copper.
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Publication type Article: Journal article
Document type Review
Corresponding Author
Keywords Acute Copper Toxicity ; Mitochondria ; Wilson Disease; Long-term Treatment; Wilsons-disease; Oxidative Stress; D-penicillamine; Intestinal Metallothionein; Dietary Copper; Amyloid-beta; Hepatocellular Mitochondria; Cellular Mechanisms; Oxidase Activity
ISSN (print) / ISBN 2213-2317
e-ISSN 2213-2317
Journal Redox Biology
Quellenangaben Volume: 75, Issue: , Pages: , Article Number: 103256 Supplement: ,
Publisher Elsevier
Publishing Place Amsterdam [u.a.]
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Molecular Toxicology and Pharmacology (TOXI)
Grants Bundesministerium fur Bildung und Forschung (BMBF)
Deutsche Forschungsgemeinschaft (DFG)