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Ehrhardt, H.* ; Häcker, S.* ; Wittmann, S.* ; Maurer, M.* ; Borkhardt, A.* ; Toloczko, A. ; Debatin, K.M.* ; Fulda, S.* ; Jeremias, I.

Editorial Expression of Concern: Cytotoxic drug-induced, p53-mediated upregulation of caspase-8 in tumor cells (Oncogene, (2008), 27, 6, (783-793), 10.1038/sj.onc.1210666).

Oncogene, DOI: 10.1038/s41388-024-03093-2 (2024)
DOI
: Publ. Version/Full Text online available 07/2029
Editorial Expression of Concern to: Oncogenehttps://doi.org/10.1038/sj.onc.1210666, published online 16 July 2007 The Editors-in-Chief would like to alert readers that concerns have been raised regarding some of the western blot data presented in figures included in this article, specifically: Fig. 1a CADO and CEM-TR a-Tubulin blots appear highly similar. Fig. 1a J-TR Casp-8 MTX+ band appears highly similar to Fig. 2e J-TR Casp-8 MTX 72h. Fig. 1a CEM-TR and CADO Casp-8 MTX+ bands appear highly similar to Fig. 5c Casp-8 Control group (also treated with MTX) in the same cell lines. Figs. 3 and 5c CADO Casp-8 and a-Tubulin blots appear highly similar. Fig. 1a CADO and CEM-TR a-Tubulin blots appear highly similar. Fig. 1a J-TR Casp-8 MTX+ band appears highly similar to Fig. 2e J-TR Casp-8 MTX 72h. Fig. 1a CEM-TR and CADO Casp-8 MTX+ bands appear highly similar to Fig. 5c Casp-8 Control group (also treated with MTX) in the same cell lines. Figs. 3 and 5c CADO Casp-8 and a-Tubulin blots appear highly similar. The authors have stated that the possible duplications were unintentional and confirmed that the issues raised do not affect the results and conclusions of the article. The original data are no longer available due to the age of the article (16 years), in line with rules of the German Research Foundation. Readers are therefore advised to interpret these figures with caution. H Ehrhardt, K-M Debatin and I Jeremias agree to this Editorial Expression of Concern. S Fulda does not agree to this Editorial Expression of Concern. A Borkhardt has not responded to any correspondence from the editor or publisher about this Editorial Expression of Concern. The publisher has not been able to obtain current email addresses for S Häcker, S Wittmann, M Maurer and A Toloczko.
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Publication type Article: Journal article
Document type Editorial
Corresponding Author
ISSN (print) / ISBN 0950-9232
e-ISSN 0950-9232
Journal Oncogene
Publisher Nature Publishing Group
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Research Unit Apoptosis in Hematopoietic Stem Cells (AHS)