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Le Thuc, O. ; García-Cáceres, C.

Obesity-induced inflammation: Connecting the periphery to the brain.

Nat. Metab., DOI: 10.1038/s42255-024-01079-8 (2024)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Obesity is often associated with a chronic, low-grade inflammatory state affecting the entire body. This sustained inflammatory state disrupts the coordinated communication between the periphery and the brain, which has a crucial role in maintaining homeostasis through humoural, nutrient-mediated, immune and nervous signalling pathways. The inflammatory changes induced by obesity specifically affect communication interfaces, including the blood-brain barrier, glymphatic system and meninges. Consequently, brain areas near the third ventricle, including the hypothalamus and other cognition-relevant regions, become susceptible to impairments, resulting in energy homeostasis dysregulation and an elevated risk of cognitive impairments such as Alzheimer's disease and dementia. This Review explores the intricate communication between the brain and the periphery, highlighting the effect of obesity-induced inflammation on brain function.
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Publication type Article: Journal article
Document type Review
Corresponding Author
Keywords Diet-induced Obesity; Beta/nf-kappa-b; Monocyte Chemoattractant Protein-1; Necrosis-factor-alpha; White Adipose-tissue; Insulin-resistance; Tnf-alpha; Hypothalamic Inflammation; Macrophage Infiltration; Alzheimers-disease
ISSN (print) / ISBN 2522-5812
e-ISSN 2522-5812
Journal Nature metabolism
Publisher Springer
Publishing Place London
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes and Obesity (IDO)
Grants Helmholtz Association - Initiative and Networking Fund
German Research Foundation DFG under Germany's Excellence Strategy
DZD