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Weinisch, P. ; Raffler, J. ; Römisch-Margl, W. ; Arnold, M. ; Mohney, R.P.* ; Rist, M.J.* ; Prehn, C. ; Skurk, T.* ; Hauner, H.* ; Daniel, H.* ; Suhre, K.* ; Kastenmüller, G.

The HuMet Repository: Watching human metabolism at work.

Cell Rep. 43:114416 (2024)
Postprint DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Metabolism oscillates between catabolic and anabolic states depending on food intake, exercise, or stresses that change a multitude of metabolic pathways simultaneously. We present the HuMet Repository for exploring dynamic metabolic responses to oral glucose/lipid loads, mixed meals, 36-h fasting, exercise, and cold stress in healthy subjects. Metabolomics data from blood, urine, and breath of 15 young, healthy men at up to 56 time points are integrated and embedded within an interactive web application, enabling researchers with and without computational expertise to search, visualize, analyze, and contextualize the dynamic metabolite profiles of 2,656 metabolites acquired on multiple platforms. With examples, we demonstrate the utility of the resource for research into the dynamics of human metabolism, highlighting differences and similarities in systemic metabolic responses across challenges and the complementarity of metabolomics platforms. The repository, providing a reference for healthy metabolite changes to six standardized physiological challenges, is freely accessible through a web portal.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Cp: Metabolism ; Dynamic Metabolic Responses In Health ; Exercise Metabolism ; Metabolic Flexibility ; Metabolomics Platform Comparison ; Oral Glucose Tolerance Test ; Oral Lipid Tolerance Test ; Postprandial Metabolism ; Prolonged/extended Fasting ; Standardized Physiological Challenge Tests ; Time-series Metabolomics; Human Blood; Metabolomics; Associations; Imputation; Pathways; Markers
Language english
Publication Year 2024
HGF-reported in Year 2024
ISSN (print) / ISBN 2211-1247
e-ISSN 2211-1247
Journal Cell Reports
Quellenangaben Volume: 43, Issue: 8, Pages: , Article Number: 114416 Supplement: ,
Publisher Cell Press
Publishing Place 50 Hampshire St, Floor 5, Cambridge, Ma 02139 Usa
Reviewing status Peer reviewed
Institute(s) Institute of Computational Biology (ICB)
CF Metabolomics & Proteomics (CF-MPC)
POF-Topic(s) 30205 - Bioengineering and Digital Health
30505 - New Technologies for Biomedical Discoveries
Research field(s) Enabling and Novel Technologies
PSP Element(s) G-503891-001
A-630710-001
Grants De.NBI Cloud within the German Network for Bio-informatics Infrastructure (de.NBI) - German Federal Ministry of Education and Research (BMBF)
National Institutes of Health/National Institute on Aging
Qatar Foundation
Biomedical Research Program at Weill Cornell Medicine in Qatar
German Federal Ministry of Education and Research (BMBF)
Else Kroner-Fresenius Foundation, Bad Homburg, Germany
DOI 10.1016/j.celrep.2024.114416
WOS ID 001276325900001
Scopus ID 85199059032
PubMed ID 39033506
Erfassungsdatum 2024-07-22
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