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The HuMet Repository: Watching human metabolism at work.
Cell Rep. 43:114416 (2024)
Metabolism oscillates between catabolic and anabolic states depending on food intake, exercise, or stresses that change a multitude of metabolic pathways simultaneously. We present the HuMet Repository for exploring dynamic metabolic responses to oral glucose/lipid loads, mixed meals, 36-h fasting, exercise, and cold stress in healthy subjects. Metabolomics data from blood, urine, and breath of 15 young, healthy men at up to 56 time points are integrated and embedded within an interactive web application, enabling researchers with and without computational expertise to search, visualize, analyze, and contextualize the dynamic metabolite profiles of 2,656 metabolites acquired on multiple platforms. With examples, we demonstrate the utility of the resource for research into the dynamics of human metabolism, highlighting differences and similarities in systemic metabolic responses across challenges and the complementarity of metabolomics platforms. The repository, providing a reference for healthy metabolite changes to six standardized physiological challenges, is freely accessible through a web portal.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Cp: Metabolism ; Dynamic Metabolic Responses In Health ; Exercise Metabolism ; Metabolic Flexibility ; Metabolomics Platform Comparison ; Oral Glucose Tolerance Test ; Oral Lipid Tolerance Test ; Postprandial Metabolism ; Prolonged/extended Fasting ; Standardized Physiological Challenge Tests ; Time-series Metabolomics; Human Blood; Metabolomics; Associations; Imputation; Pathways; Markers
ISSN (print) / ISBN
2211-1247
e-ISSN
2211-1247
Journal
Cell Reports
Quellenangaben
Volume: 43,
Issue: 8,
Article Number: 114416
Publisher
Cell Press
Publishing Place
50 Hampshire St, Floor 5, Cambridge, Ma 02139 Usa
Non-patent literature
Publications
Reviewing status
Peer reviewed
Grants
De.NBI Cloud within the German Network for Bio-informatics Infrastructure (de.NBI) - German Federal Ministry of Education and Research (BMBF)
National Institutes of Health/National Institute on Aging
Qatar Foundation
Biomedical Research Program at Weill Cornell Medicine in Qatar
German Federal Ministry of Education and Research (BMBF)
Else Kroner-Fresenius Foundation, Bad Homburg, Germany
National Institutes of Health/National Institute on Aging
Qatar Foundation
Biomedical Research Program at Weill Cornell Medicine in Qatar
German Federal Ministry of Education and Research (BMBF)
Else Kroner-Fresenius Foundation, Bad Homburg, Germany