Clues to quality of journals
Open Access Policy of Helmholtz Association 2016
CC Licencences
Publication Metrics
Home
Deutsch
New EVA Application
Advanced Search
Browse by ...
Publication overview
Statistics (last 5 years)
OA Publications
Submit Publication
Import publication from...
Report missing publication
Contact persons
Help
Text
Endnote (RIS)
BibTeX
Publ. Version/Full Text
DOI
 |
Open Access Hybrid |
|
as soon as is submitted to ZB.
Inkjet-printed 3D electrode arrays for recording signals from cortical organoids.
Adv. Mater. Technol., DOI: 10.1002/admt.202400645 (2024)
Monitoring electrical activity across multiple planes in 3D cell cultures and organoids is imperative to comprehensively understand their functional connections and behavior. However, traditional planar microelectrode arrays (MEAs) are intended for surface recordings and are inadequate in addressing this aspect. The limitations, such as longer production times and limited adaptability imposed by standard clean-room techniques, constrain the design possibilities for 3D electrode arrays and potentially hinder effective cell-electrode coupling. To tackle this challenge, a novel approach is presented that leverages rapid prototyping processes and additive manufacturing in combination with wet etching and electrodeposition to enhance electrode fabrication and performance. The laser-patterned MEAs on glass, polyimide (PI) foil, or polyethylene terephthalate (PET) foil substrates incorporate high-aspect ratio (up to 44:1) ink-jet printed 3D electrode structures with heights up to 1 mm at a pitch of 200 µm, enabling precise recording within cell tissues. The specific shapes of the electrode tips and customizable 3D structures provide great flexibility in electrode placement. The versatility of the 3D MEAs is demonstrated by recording the electrophysiological activity of cortical organoids in situ, paving the way for investigating neural activity under regular or various pathologically altered conditions in vitro in a high throughput manner.
Impact Factor
Scopus SNIP
Altmetric
6.400
0.000
Annotations
Special Publikation
Hide on homepage
Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Extracellular Recording ; Microelectrode Arrays ; Microfabrication ; Neuroelectronics ; Organoids; Microelectrode Array; Brain; Stimulation; Devices
Language
english
Publication Year
2024
HGF-reported in Year
2024
ISSN (print) / ISBN
2365-709X
e-ISSN
2365-709X
Journal
Advanced Materials Technologies
Publisher
Wiley
Publishing Place
111 River St, Hoboken, Nj 07030 Usa
Reviewing status
Peer reviewed
Institute(s)
Insitute of Synthetic Biomedicine (ISBM)
POF-Topic(s)
30205 - Bioengineering and Digital Health
Research field(s)
Enabling and Novel Technologies
PSP Element(s)
G-509300-001
Grants
Federal Ministry of Education and Research (BMBF)
WOS ID
001271533500001
Scopus ID
85198850117
Erfassungsdatum
2024-07-23