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Open Access Green as soon as Postprint is submitted to ZB.
Production and Purification of Adeno-Associated Viral Vectors for the Development of Immune-Competent Mouse Models of Persistent Hepatitis B Virus Replication.
In: Hepatitis B Virus. Berlin [u.a.]: Springer, 2024. 207-218 (Methods Mol. Biol. ; 2837)
Mice infected with a recombinant adeno-associated virus carrying a replication-competent hepatitis B virus genome (rAAV-HBV) via the intravenous route establish a persistent HBV replication in hepatocytes and develop immune tolerance. They serve as models to evaluate antiviral immunity and to assess potential therapeutic approaches for chronic HBV infection. Combining selected HBV variants and different mouse genotypes allows for addressing a broad spectrum of research questions. This chapter describes the basic principles of the rAAV-HBV mouse model, rAAV-HBV production and purification methods, and finally, the in vivo application.
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Publication type
Article: Edited volume or book chapter
Keywords
Adeno-associated Virus ; Cchronic Hbv Infection ; Gene Transfer ; Hbv Variants ; Hepatitis B Virus ; Iodixanol Purification ; Mouse Model
ISSN (print) / ISBN
1064-3745
e-ISSN
1940-6029
Book Volume Title
Hepatitis B Virus
Journal
Methods in Molecular Biology
Quellenangaben
Volume: 2837,
Pages: 207-218
Publisher
Springer
Publishing Place
Berlin [u.a.]
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Virology (VIRO)