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Chen, B.* ; de Launoit, E.* ; Meseguer, D.* ; García-Cáceres, C. ; Eichmann, A.* ; Renier, N.* ; Schneeberger, M.*

The interactions between energy homeostasis and neurovascular plasticity.

Nat. Rev. Endocrinol., DOI: 10.1038/s41574-024-01021-8 (2024)
DOI PMC
Open Access Green: Postprint online available 01/2025
Food intake and energy expenditure are sensed and processed by multiple brain centres to uphold energy homeostasis. Evidence from the past decade points to the brain vasculature as a new critical player in regulating energy balance that functions in close association with the local neuronal networks. Nutritional imbalances alter many properties of the neurovascular system (such as neurovascular coupling and blood-brain barrier permeability), thus suggesting a bidirectional link between the nutritional milieu and neurovascular health. Increasing numbers of people are consuming a Western diet (comprising ultra-processed food with high-fat and high-sugar content) and have a sedentary lifestyle, with these factors contributing to the current obesity epidemic. Emerging pharmacological interventions (for example, glucagon-like peptide 1 receptor agonists) successfully trigger weight loss. However, whether these approaches can reverse the detrimental effects of long-term exposure to the Western diet (such as neurovascular uncoupling, neuroinflammation and blood-brain barrier disruption) and maintain stable body weight in the long-term needs to be clarified in addition to possible adverse effects. Lifestyle interventions revert the nutritional trigger for obesity and positively affect our overall health, including the cardiovascular system. This Perspective examines how lifestyle interventions affect the neurovascular system and neuronal networks.
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Publication type Article: Journal article
Document type Review
Corresponding Author
Keywords Cerebral-blood-flow; Brain Glucose-uptake; High-fat Diet; Life-style; Cerebrovascular Reactivity; Body-composition; Restriction; Obesity; Barrier; Lactate
ISSN (print) / ISBN 1759-5029
e-ISSN 1759-5037
Journal Nature Reviews - Endocrinology
Publisher Nature Publishing Group
Publishing Place New York, NY
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes and Obesity (IDO)
Grants National Institute of Diabetes, Digestive and Kidney Diseases
Interstellar Initiative (NYAS/AMED)
E. Matilda Ziegler Foundation
McCluskey family