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Radushev, V.* ; Karkossa, I.* ; Berg, J.* ; von Bergen, M.* ; Engelmann, B.* ; Rolle-Kampczyk, U.* ; Blüher, M. ; Wagner, U.* ; Schubert, K.* ; Rossol, M.*

Dysregulated cytokine and oxidative response in hyper-glycolytic monocytes in obesity.

Front. Immunol. 15:1416543 (2024)
Publ. Version/Full Text DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
INTRODUCTION: Obesity is associated with a plethora of health complications, including increased susceptibility to infections or decreased vaccine efficacy, partly due to dysregulated immune responses. Monocytes play a crucial role in innate immunity, yet their functional alterations in obesity remain poorly understood. METHODS: Here, we employed proteomic and metabolomic analyses to investigate monocyte characteristics in individuals with overweight, obesity, impaired glucose tolerance (IGT), and type 2 diabetes (T2D), compared to lean donors. RESULTS AND DISCUSSION: Our results revealed distinct molecular signatures in monocytes from individuals with obesity, with significant alterations in pathways related to metabolism, cellular migration, and phagocytosis. Moreover, LPS-induced activation of monocytes unveiled heightened metabolic reprogramming towards glycolysis in subjects with obesity accompanied by dysregulated cytokine responses and elevated oxidative stress. Additionally, monocytes from donors with obesity exhibited increased lipid droplet accumulation. These findings shed light on the immunometabolic dysregulation underlying obesity-associated immune dysfunction, highlighting potential targets for therapeutic intervention.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Il-8 ; Immunometabolism ; Monocytes ; Obesity ; Respiratory Burst
ISSN (print) / ISBN 1664-3224
e-ISSN 1664-3224
Journal Frontiers in Immunology
Quellenangaben Volume: 15, Issue: , Pages: , Article Number: 1416543 Supplement: ,
Publisher Frontiers
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Helmholtz Institute for Metabolism, Obesity and Vascular Research (HI-MAG)