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Herder, C.* ; Saito, Y.* ; Spagnuolo, M.* ; Maalmi, H.* ; Shimizu, M.* ; Bönhof, G.J.* ; Suzuki, K.* ; Rathmann, W.* ; Peters, A. ; Roden, M.* ; Ziegler, D.* ; Thorand, B. ; Takamura, T.*

Differential associations between selenoprotein P and distal sensorimotor polyneuropathy in people with and without diabetes: KORA F4/FF4 study.

Free Radical Biol. Med. 223, 87-95 (2024)
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BACKGROUND: Oxidative stress is a risk factor for distal sensorimotor polyneuropathy (DSPN). Selenoprotein P is a protein with antioxidant properties but has not been investigated in the context of DSPN. This study aimed to assess the associations between selenoprotein P and DSPN in people without and with type 2 diabetes (T2D). METHODS: Cross-sectional and prospective analyses were based on 1053 (including 217 with T2D) and 513 participants (including 79 with T2D), respectively, aged 61-82 years from the population-based KORA F4 survey. DSPN at baseline (KORA F4) and in the follow-up survey KORA FF4 was defined based on the Michigan Neuropathy Screening Instrument. Serum levels of full-length selenoprotein P were quantified by ELISA. Associations between selenoprotein P and prevalent or incident DSPN were estimated using logistic regression analysis adjusting for multiple confounders. RESULTS: Selenoprotein P levels were not associated with prevalent DSPN in the total sample. However, there was a significant interaction by diabetes status. Higher levels of selenoprotein P were associated with lower odds of prevalent DSPN in individuals without T2D (fully adjusted model: OR 0.825 [95% CI 0.682, 0.998], p=0.0476), but not in those with T2D (OR [95% CI] 1.098 [0.829, 1.454], p=0.5132; pinteraction=0.0488). Selenoprotein P levels were not associated with incident DSPN over a follow-up of 6.5 years. CONCLUSION: In individuals without T2D from the older general population, lower selenoprotein P levels were associated with a higher prevalence of DSPN. Whether the antioxidant properties of selenoprotein P are responsible for the observed associations remains to be elucidated in future research.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Antioxidant ; Biomarker ; Distal Sensorimotor Polyneuropathy ; Oxidative Stress ; Reductive Stress ; Selenoprotein P; Neurological Dysfunction; Oxidative Stress; Mice; Neurodegeneration; Progression; Population; Protein
Language english
Publication Year 2024
HGF-reported in Year 2024
ISSN (print) / ISBN 0891-5849
e-ISSN 1873-4596
Journal Free Radical Biology and Medicine
Quellenangaben Volume: 223, Issue: , Pages: 87-95 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place New York, NY
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
POF-Topic(s) 30202 - Environmental Health
Research field(s) Genetics and Epidemiology
PSP Element(s) G-504000-002
G-504000-010
Grants Japan Agency for Medical Research and Development (AMED)
Ministry of Culture and Science of the state North Rhine-Westphalia (Dusseldorf, Germany)
German Federal Ministry of Education and Research (BMBF) through the German Center for Diabetes Research (DZD e.V.)
Helmholtz Zentrum Munchen - German Research Center for Environmental Health - German Federal Ministry of Education and Research (BMBF)
State of Bavaria
JSPS KAKENHI
German Federal Ministry of Health (Berlin, Germany)
DOI 10.1016/j.freeradbiomed.2024.07.028
WOS ID 001286702700001
Scopus ID 85199948758
PubMed ID 39059514
Erfassungsdatum 2024-08-01
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