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Wang, T.* ; Sharma, A.K.* ; Wu, C.* ; Maushart, C.I.* ; Ghosh, A.* ; Yang, W.* ; Stefanicka, P.* ; Kovanicova, Z.* ; Ukropec, J.* ; Zhang, J.* ; Arnold, M.* ; Klug, M.* ; de Bock, K.* ; Schneider, U.* ; Popescu, C.* ; Zheng, B.* ; Ding, L.* ; Long, F.* ; Dewal, R.S.* ; Moser, C.* ; Sun, W.* ; Dong, H.* ; Takes, M.* ; Suelberg, D.* ; Mameghani, A.* ; Nocito, A.* ; Zech, C.J.* ; Chirindel, A.* ; Wild, D.* ; Burger, I.A.* ; Schön, M.R.* ; Dietrich, A.* ; Gao, M.* ; Heine, M.* ; Sun, Y.* ; Vargas-Castillo, A.* ; Søberg, S.* ; Scheele, C.* ; Balaz, M.* ; Blüher, M. ; Betz, M.J.* ; Spiegelman, B.M.* ; Wolfrum, C.*

Single-nucleus transcriptomics identifies separate classes of UCP1 and futile cycle adipocytes.

Cell Metab. 36, DOI: 10.1016/j.cmet.2024.07.005 (2024)
Publ. Version/Full Text DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
Adipose tissue can recruit catabolic adipocytes that utilize chemical energy to dissipate heat. This process occurs either by uncoupled respiration through uncoupling protein 1 (UCP1) or by utilizing ATP-dependent futile cycles (FCs). However, it remains unclear how these pathways coexist since both processes rely on the mitochondrial membrane potential. Utilizing single-nucleus RNA sequencing to deconvolute the heterogeneity of subcutaneous adipose tissue in mice and humans, we identify at least 2 distinct subpopulations of beige adipocytes: FC-adipocytes and UCP1-beige adipocytes. Importantly, we demonstrate that the FC-adipocyte subpopulation is highly metabolically active and utilizes FCs to dissipate energy, thus contributing to thermogenesis independent of Ucp1. Furthermore, FC-adipocytes are important drivers of systemic energy homeostasis and linked to glucose metabolism and obesity resistance in humans. Taken together, our findings identify a noncanonical thermogenic adipocyte subpopulation, which could be an important regulator of energy homeostasis in mammals.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Energy Homeostasis ; Futile Cycling ; Human Metabolism ; Single-nucleus Rna Sequencing ; Thermogenesis
ISSN (print) / ISBN 1550-4131
e-ISSN 1932-7420
Journal Cell Metabolism
Quellenangaben Volume: 36 Issue: , Pages: , Article Number: , Supplement: ,
Publisher Elsevier
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Helmholtz Institute for Metabolism, Obesity and Vascular Research (HI-MAG)