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Regional gray matter changes in steatotic liver disease provide a neurobiological link to depression: A cross-sectional UK biobank cohort study.
Metabolism 159:155983 (2024)
BACKGROUND: Steatotic liver disease (SLD) is characterized by excessive accumulation of lipids in the liver. It is associated with elevated risk of hepatic and cardiometabolic diseases, as well as mental disorders such as depression. Previous studies revealed global gray matter reduction in SLD. To investigate a possible shared neurobiology with depression, we examined liver-fat-related regional gray matter alterations in SLD and its most significant clinical subgroup metabolic dysfunction-associated steatotic liver disease (MASLD). METHODS: We analyzed regional cortical thickness and area obtained from brain MRI in 29,051 participants in UK Biobank. Liver fat amount was computed as proton density fat fraction (PDFF) from liver MRI scans. We examined the relationship between brain structure and PDFF, adjusting for sociodemographic, physical, lifestyle, and environmental factors, as well as alcohol intake and a spectrum of cardiometabolic covariates. Finally, we compared patterns of brain alterations in SLD/MASLD and major depressive disorder (MDD) using previously published results. RESULTS: PDFF-related gray matter alterations were region-specific, involving both increases and decreases in cortical thickness, and increased cortical area. In several regions, PDFF effects on gray matter could also be attributed to cardiometabolic covariates. However, PDFF was consistently associated with lower cortical thickness in middle and superior temporal areas and higher cortical thickness in pericalcarine and right frontal pole areas. PDFF-related alterations for the SLD and the MASLD group correlated with those observed in MDD (Pearson r = 0.45-0.54, p < 0.01). CONCLUSION: These findings suggest the presence of shared biological mechanisms linking MDD to SLD and MASLD. They might explain the well-known elevated risk of depression in these groups and support early lifestyle interventions and treatment of metabolic risk factors for the successful management of the interconnected diseases depression and SLD/MASLD.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Masld ; Major Depression ; Nafld ; Proton Density Fat Fraction ; Steatosis ; Smri; Middle-aged Adults; Body-mass Index; Social Cognition; Brain Structure; Inflammation; Association; Prevalence; Disorder; Obesity; Health
ISSN (print) / ISBN
0026-0495
e-ISSN
1532-8600
Quellenangaben
Volume: 159,
Article Number: 155983
Publisher
Elsevier
Publishing Place
1600 John F Kennedy Boulevard, Ste 1800, Philadelphia, Pa 19103-2899 Usa
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute for Pancreatic Beta Cell Research (IPI)
Grants
German Ministry of Research and Education-Bundesministerium fur Bildung und Foschung (BMBF) - Deutsches Zentrum fur Diabetesforschung (DZD e.V.)
Consortium of the German Research Foundation (DFG)
International Research Training Group "Risk Factors and Pathomechanisms of Affective Disorders"
Else Kroner-Fresenius-Stiftung
Consortium of the German Research Foundation (DFG)
International Research Training Group "Risk Factors and Pathomechanisms of Affective Disorders"
Else Kroner-Fresenius-Stiftung