PuSH - Publication Server of Helmholtz Zentrum München: CD44 signaling in Müller cells impacts photoreceptor function and survival in healthy and diseased retinas.

Navigation

Home

Deutsch

Research

Advanced Search

Browse by ...

... Journal

... Publication Type

... Research Data

... Publication Year

Publication overview

Support & Contact

Contact persons

Help

Data protection

Ayten, M.* ; Straub, T.* ; Kaplan, L.* ; Hauck, S.M. ; Grosche, A.* ; Koch, S.F.*

CD44 signaling in Müller cells impacts photoreceptor function and survival in healthy and diseased retinas.

J. Neuroinflamm. 21:190 (2024)

Publ. Version/Full Text

DOI

PMC

	Open Access Gold

Abstract
Metrics
Extra information

Retinitis pigmentosa (RP), an inherited retinal disease, affects 1,5 million people worldwide. The initial mutation-driven photoreceptor degeneration leads to chronic inflammation, characterized by Müller cell activation and upregulation of CD44. CD44 is a cell surface transmembrane glycoprotein and the primary receptor for hyaluronic acid. It is involved in many pathological processes, but little is known about CD44's retinal functions. CD44 expression is also increased in Müller cells from our Pde6b^STOP/STOP RP mouse model. To gain a more detailed understanding of CD44's role in healthy and diseased retinas, we analyzed Cd44^-/- and Cd44^-/-Pde6b^STOP/STOP mice, respectively. The loss of CD44 led to enhanced photoreceptor degeneration, reduced retinal function, and increased inflammatory response. To understand the underlying mechanism, we performed proteomic analysis on isolated Müller cells from Cd44^-/- and Cd44^-/-Pde6b^STOP/STOP retinas and identified a significant downregulation of glutamate transporter 1 (SLC1A2). This downregulation was accompanied by higher glutamate levels, suggesting impaired glutamate homeostasis. These novel findings indicate that CD44 stimulates glutamate uptake via SLC1A2 in Müller cells, which in turn, supports photoreceptor survival and function.

Altmetric

Additional Metrics?

[➜Log in]

Edit extra informations Login

Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Cd44 ; Gliosis ; Glutamate ; Inflammation ; Müller Cells ; Retinitis Pigmentosa ; Slc1a2; Muller Glia; Extracellular-matrix; Transcriptional Regulation; Glutamate Transporters; Retinitis-pigmentosa; Preclinical Model; Up-regulation; Inflammation; Hyaluronan; Expression

ISSN (print) / ISBN 1742-2094

e-ISSN 1742-2094

Journal Journal of Neuroinflammation

Quellenangaben Volume: 21, Issue: 1, Article Number: 190

Publisher BioMed Central

Publishing Place London

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) CF Metabolomics & Proteomics (CF-MPC)

Grants Ludwig-Maximilians-Universitt Mnchen (1024)