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Decoster, L.* ; Trova, S.* ; Zucca, S.* ; Bulk, J.* ; Gouveia, A.* ; Ternier, G.* ; Lhomme, T.* ; Legrand, A.* ; Gallet, S.* ; Boehm, U.* ; Wyatt, A.* ; Wahl, V.* ; Wartenberg, P.* ; Hrabovszky, E.* ; Rácz, G.* ; Luzzati, F.* ; Nato, G.* ; Fogli, M.* ; Peretto, P.* ; Schriever, S.C. ; Bernecker, M. ; Pfluger, P.T. ; Steculorum, S.M.* ; Bovetti, S.* ; Rasika, S.* ; Prévot, V.* ; Silva, M.S.B.* ; Giacobini, P.*

A GnRH neuronal population in the olfactory bulb translates socially relevant odors into reproductive behavior in male mice.

Nat. Neurosci. 27, 1758-1773 (2024)

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Open Access Green as soon as Postprint is submitted to ZB.

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Hypothalamic gonadotropin-releasing hormone (GnRH) neurons regulate fertility and integrate hormonal status with environmental cues to ensure reproductive success. Here we show that GnRH neurons in the olfactory bulb (GnRH^OB) of adult mice can mediate social recognition. Specifically, we show that GnRH^OB neurons extend neurites into the vomeronasal organ and olfactory epithelium and project to the median eminence. GnRH^OB neurons in males express vomeronasal and olfactory receptors, are activated by female odors and mediate gonadotropin release in response to female urine. Male preference for female odors required the presence and activation of GnRH^OB neurons, was impaired after genetic inhibition or ablation of these cells and relied on GnRH signaling in the posterodorsal medial amygdala. GnRH receptor expression in amygdala kisspeptin neurons appear to be required for GnRH^OB neurons' actions on male mounting behavior. Taken together, these results establish GnRH^OB neurons as regulating fertility, sex recognition and mating in male mice.

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Publication type Article: Journal article

Document type Scientific Article

Keywords Luteinizing-hormone Secretion; Hypogonadotropic Hypogonadism; Corticomedial Amygdala; Vomeronasal Organ; Golden-hamster; Feedback; Recognition; Connections; Projections; Activation

ISSN (print) / ISBN 1097-6256

e-ISSN 1546-1726

Journal Nature Neuroscience

Quellenangaben Volume: 27, Issue: 9, Pages: 1758-1773

Publisher Nature Publishing Group

Publishing Place Heidelberger Platz 3, Berlin, 14197, Germany

Reviewing status Peer reviewed

Institute(s) Institute of Diabetes and Obesity (IDO)

Grants Agence Nationale de la Recherche (ANR)
Lille In vivo Imaging and Functional Exploration platform (Univ.)
CNRS
Inserm, CHU Lille
Institut Pasteur of Lille
European Research Council under the European Union's Horizon 2020 Research and Innovation program
Agence Nationale de la Recherche
INSERM-France
EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council)