PuSH - Publication Server of Helmholtz Zentrum München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Ling, F. ; Essock-Burns, T.* ; McFall-Ngai, M.* ; Katija, K.* ; Nawroth, J. ; Kanso, E.*

Flow physics guides morphology of ciliated organs.

Nat. Phys. 20, 1679-1686 (2024)
Publ. Version/Full Text Postprint Research data DOI PMC
Open Access Green
Organs that pump luminal fluids by the coordinated beat of motile cilia are integral to animal physiology. Such organs include the human airways, brain ventricles and reproductive tracts. Although cilia organization and duct morphology vary drastically in the animal kingdom, ducts are typically classified as carpet or flame designs. The reason behind the appearance of these two different designs and how they relate to fluid pumping remain unclear. Here, we demonstrate that two structural parameters—lumen diameter and cilia-to-lumen ratio—organize the observed duct diversity into a continuous spectrum that connects carpets to flames across all animal phyla. Using a unified fluid model, we show that carpets and flames represent trade-offs between flow rate and pressure generation. We propose that the convergence of ciliated organ designs follows functional constraints rather than phylogenetic distance and offer guiding design principles for synthetic ciliary pumps.
Impact Factor
Scopus SNIP
Altmetric
18.100
4.424
Tags
Annotations
Special Publikation
Hide on homepage

Edit extra information
Edit own tags
Private
Edit own annotation
Private
Hide on publication lists
on hompage
Mark as special
publikation
Publication type Article: Journal article
Document type Scientific Article
Keywords Excretory System; Neural Gland; Transport; Patterns; Regeneration; Sponges; Model
Language english
Publication Year 2024
HGF-reported in Year 2024
ISSN (print) / ISBN 1745-2473
e-ISSN 1745-2481
Journal Nature Physics
Quellenangaben Volume: 20, Issue: 10, Pages: 1679-1686 Article Number: , Supplement: ,
Publisher Springer
Publishing Place Heidelberger Platz 3, Berlin, 14197, Germany
Reviewing status Peer reviewed
Institute(s) Helmholtz Pioneer Campus (HPC)
Institute of Biological and Medical Imaging (IBMI)
POF-Topic(s) 30203 - Molecular Targets and Therapies
30205 - Bioengineering and Digital Health
Research field(s) Pioneer Campus
Enabling and Novel Technologies
PSP Element(s) G-510009-001
G-505500-001
Grants European Research Council (ERC)
National Science Foundation
National Institutes of Health
European Research Council
COBRE
David & Lucile Packard Foundation
National Science Foundation (DBI)
Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.)
DOI 10.1038/s41567-024-02591-0
WOS ID 001279238900010
Scopus ID 85199967190
PubMed ID 40129718
Erfassungsdatum 2024-09-04
[➜Report correction]