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Ageing-related bone and immunity changes: Insights into the complex interplay between the skeleton and the immune system.
Bone Res. 12:42 (2024)
Ageing as a natural irreversible process inherently results in the functional deterioration of numerous organ systems and tissues, including the skeletal and immune systems. Recent studies have elucidated the intricate bidirectional interactions between these two systems. In this review, we provide a comprehensive synthesis of molecular mechanisms of cell ageing. We further discuss how age-related skeletal changes influence the immune system and the consequent impact of immune system alterations on the skeletal system. Finally, we highlight the clinical implications of these findings and propose potential strategies to promote healthy ageing and reduce pathologic deterioration of both the skeletal and immune systems.
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Publication type
Article: Journal article
Document type
Review
Keywords
Hematopoietic Stem-cells; Regulatory T-cells; Senescent Cells; Osteoblast Differentiation; Secretory Phenotype; Aged Mice; Marrow; Impact; Osteogenesis; Osteoporosis
ISSN (print) / ISBN
2095-4700
e-ISSN
2095-6231
Journal
Bone Research
Quellenangaben
Volume: 12,
Issue: 1,
Article Number: 42
Publisher
Springer
Publishing Place
Campus, 4 Crinan St, London, N1 9xw, England
Reviewing status
Peer reviewed
Institute(s)
Institute of Regenerative Biology and Medicine (IRBM)
Grants
CUHK
Research Grants Council of the Hong Kong Special Administrative Region, China
University Grants Committee
Wuhan Science and Technology Bureau
National Key R&D Program of China
Research Grants Council of the Hong Kong Special Administrative Region, China
University Grants Committee
Wuhan Science and Technology Bureau
National Key R&D Program of China