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Dynamic interactions drive early spliceosome assembly.
Curr. Opin. Struct. Biol. 88:102907 (2024)
Splicing is a critical processing step during pre-mRNA maturation in eukaryotes. The correct selection of splice sites during the early steps of spliceosome assembly is highly important and crucial for the regulation of alternative splicing. Splice site recognition and alternative splicing depend on cis-regulatory sequence elements in the RNA and trans-acting splicing factors that recognize these elements and crosstalk with the canonical splicing machinery. Structural mechanisms involving early spliceosome complexes are governed by dynamic RNA structures, protein-RNA interactions and conformational flexibility of multidomain RNA binding proteins. Here, we highlight structural studies and integrative structural biology approaches, which provide complementary information from cryo-EM, NMR, small angle scattering, and X-ray crystallography to elucidate mechanisms in the regulation of early spliceosome assembly and quality control, highlighting the role of conformational dynamics.
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Publication type
Article: Journal article
Document type
Review
Keywords
Site Recognition; Protein Recognition; Splicing Regulation; Structural Basis; Rna Recognition; Snrnp; Exon; Association; Regulator; Selection
ISSN (print) / ISBN
0959-440X
e-ISSN
1879-033X
Quellenangaben
Volume: 88,
Article Number: 102907
Publisher
Elsevier
Publishing Place
84 Theobalds Rd, London Wc1x 8rr, England
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Structural Biology (STB)
Grants
European Union
Deutsche Forschungsgemeinschaft
Deutsche Forschungsgemeinschaft