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Basophil activation test in Hymenoptera venom allergy.
Allergol. Select 8, 293-298 (2024)
Before starting venom-specific immunotherapy (VIT), systemic sting reactions to Hymenoptera venoms require allergological workup in order to prove an IgE-mediated reaction and to identify the culprit insect venom. In addition to skin tests and the determination of specific IgE antibodies, the basophil activation test (BAT) using flow cytometry has emerged as a powerful tool and sensitive marker for this purpose in recent years. BAT seems to have a better informative value in terms of clinical relevance compared to the other tests. In Hymenoptera venom allergies, BAT is particularly useful for the diagnosis of cases with unclear or contradictory history and sensitization profile. Its results are associated with adverse reactions during VIT and efficacy of VIT and therefore have a certain predictive value for side effects and treatment failure of VIT. In research, it is mainly used to characterize the allergenic components of Hymenoptera venoms. This review article focuses on these topics.
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Publication type
Article: Journal article
Document type
Review
Keywords
Hymenoptera Venom Allergy ; Basophil Activation Test ; Component Resolved Diagnosis ; Venom Immunotherapy
ISSN (print) / ISBN
2512-8957
e-ISSN
2512-8957
Journal
Allergologie Select
Quellenangaben
Volume: 8,
Pages: 293-298
Publisher
Dustri
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute for Allergy Research (IAF)