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Aziz, K.* ; Koffler, D.* ; Vassantachart, A.* ; Rattani, A.* ; Ankrah, N.K.* ; Gogineni, E.* ; Andraos, T.Y.* ; Sahgal, A.* ; Vellayappan, B.* ; Dunne, E.M.* ; Siva, S.* ; Moraes, F.Y.* ; Guckenberger, M.* ; Lubelski, D.* ; Chao, S.* ; Combs, S.E. ; Chang, E.L.* ; Amin, A.G.* ; Foote, M.* ; Gibbs, I.* ; Kim, M.* ; Palmer, J.* ; Lo, S.S.* ; Redmond, K.J.*

Radiosurgery society case-based guide to stereotactic body radiation therapy for challenging cases of spinal metastases.

Pract. Radiat. Oncol. 15, 54-68 (2024)

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Open Access Green as soon as Postprint is submitted to ZB.

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PURPOSE: Spinal stereotactic body radiation therapy (SBRT) has become the standard of care in management of patients with limited sites of metastatic disease, radio-resistant histologies, painful vertebral metastases with long life expectancy and cases of reirradiation. Our case-based guidelines aim to assist radiation oncologists in the appropriate utilization of SBRT for common, yet challenging, cases of spinal metastases. MATERIALS AND METHODS: Cases were selected to include scenarios of large volume sacral disease with nerve entrapment, medically inoperable disease abutting the thecal sac, and local failure after prior SBRT. Relevant literature was reviewed, and areas requiring further investigation were discussed to offer a framework for evidence-based clinical practice. RESULTS: Spinal SBRT can be effectively delivered in challenging cases following multidisciplinary discussion by utilizing a methodical approach to patient selection, appropriate dose selection, and adherence to evidence-based dose constraints. CONCLUSIONS: The Radiosurgery Society's case-based practice review offers guidance to practicing physicians treating technically challenging SBRT candidate patients with spinal metastases.

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Publication type Article: Journal article

Document type Scientific Article

Keywords Vertebral Compression Fracture; Oligometastatic Disease; Consensus Guidelines; Sacral Metastases; Phase 2/3; Radiotherapy; Outcomes; Cancer; Recommendations; Oncology

ISSN (print) / ISBN 1879-8500

e-ISSN 1879-8519

Journal Practical Radiation Oncology

Quellenangaben Volume: 15, Issue: 1, Pages: 54-68

Publisher Elsevier

Publishing Place Ste 800, 230 Park Ave, New York, Ny 10169 Usa

Reviewing status Peer reviewed

Institute(s) Institute of Radiation Medicine (IRM)

Grants Pharmaceuticals
Merck Sharp Dohme
Roche Pharmaceuticals
American Society of Radiation Oncology Science Council
Advanced Radiotherapy Techniques committee of the International Association for the Study of Lung Cancer