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Coenen, P.* ; Huysmans, M.A.* ; Holtermann, A.* ; Troiano, R.P.* ; Mork, P.J.* ; Krokstad, S.* ; Clays, E.* ; Cillekens, B.* ; de Bacquer, D.* ; Aadahl, M.* ; Kårhus, L.L.* ; Sjøl, A.* ; Andersen, L.B.* ; Kauhanen, J.* ; Voutilainen, A.* ; Pulsford, R.M.* ; Stamatakis, E.* ; Goldbourt, U.* ; Peters, A. ; Thorand, B. ; Rosengren, A.* ; Björck, L.* ; Sprow, K.* ; Franzon, K.* ; Rodríguez-Barranco, M.* ; Luján-Barroso, L.* ; Knutsson, A.* ; Alfredsson, L.* ; Bahls, M.* ; Ittermann, T.* ; Kluttig, A.* ; Hassan, L.* ; Wanner, M.* ; Bopp, M.* ; Marott, J.L.* ; Schnohr, P.* ; Nordestgaard, B.G.* ; Dalene, K.E.* ; Ekelund, U.* ; Clausen, J.* ; Jensen, M.T.* ; Petersen, C.B.* ; Krause, N.* ; Twisk, J.* ; Mechelen, W.V.* ; van der Beek, A.J.*

Associations of occupational and leisure-time physical activity with all-cause mortality: an individual participant data meta-analysis.

Br. J. Sports Med. 58, 1527-1538 (2024)
Publ. Version/Full Text DOI PMC
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OBJECTIVE: Health effects of different physical activity domains (ie, during leisure time, work and transport) are generally considered positive. Using Active Worker consortium data, we assessed independent associations of occupational and leisure-time physical activity (OPA and LTPA) with all-cause mortality. DESIGN: Two-stage individual participant data meta-analysis. DATA SOURCE: Published and unpublished cohort study data. ELIGIBILITY CRITERIA: Working participants aged 18-65 years. METHODS: After data harmonisation, we assessed associations of OPA and LTPA with all-cause mortality. In stage 1, we analysed data from each study separately using Cox survival regression, and in stage 2, we pooled individual study findings with random-effects modelling. RESULTS: In 22 studies with up to 590 497 participants from 11 countries, during a mean follow-up of 23.1 (SD: 6.8) years, 99 743 (16%) participants died. Adjusted for LTPA, body mass index, age, smoking and education level, summary (ie, stage 2) hazard ration (HRs) and 95% confidence interval (95% CI) for low, moderate and high OPA among men (n=2 96 134) were 1.01 (0.99 to 1.03), 1.05 (1.01 to 1.10) and 1.12 (1.03 to 1.23), respectively. For women (n=2 94 364), HRs (95% CI) were 0.98 (0.92 to 1.04), 0.96 (0.92 to 1.00) and 0.97 (0.86 to 1.10), respectively. In contrast, higher levels of LTPA were inversely associated with mortality for both genders. For example, for women HR for low, moderate and high compared with sedentary LTPA were 0.85 (0.81 to 0.89), 0.78 (0.74 to 0.81) and 0.75 (0.65 to 0.88), respectively. Effects were attenuated when adjusting for income (although data on income were available from only 9 and 6 studies, for men and women, respectively). CONCLUSION: Our findings indicate that OPA may not result in the same beneficial health effects as LTPA.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Public Health; Acute Myocardial-infarction; Cardiovascular-disease; Heart-disease; Follow-up; Activity Paradox; Risk; Health; Men; Work; Life
Language english
Publication Year 2024
HGF-reported in Year 2024
ISSN (print) / ISBN 0306-3674
e-ISSN 1473-0480
Journal British Journal of Sports Medicine
Quellenangaben Volume: 58, Issue: 24, Pages: 1527-1538 Article Number: , Supplement: ,
Publisher BMJ Publishing Group
Publishing Place British Med Assoc House, Tavistock Square, London Wc1h 9jr, England
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
POF-Topic(s) 30202 - Environmental Health
Research field(s) Genetics and Epidemiology
PSP Element(s) G-504000-010
G-504000-002
Grants State of Bavaria
ZonMw
Federal Ministry for Education and Research (BMBF)
Deutsche Forschungsgemeinschaft (DFG)
DFG
Wilhelm-Roux- Programme of the Martin- Luther- University of Halle- Wittenberg
Federal Employment Office
Ministry of Education and Cultural Affairs of Saxony- Anhalt
Ministry of Economics, Science and Digitization of Saxony- Anhalt via the EU European Regional Development Fund (ERDF)
Helmholtz Zentrum Munchen-German Research Center for Environmental Health
Swedish Research Council
German Federal Ministry of Education and Research (BMBF)
The Netherlands Organisation for Health Research and Development
DOI 10.1136/bjsports-2024-108117
WOS ID 001385698100008
WOS ID 001319717000001
Scopus ID 85204188096
PubMed ID 39255999
Erfassungsdatum 2024-10-23
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