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Cillekens, B.* ; Coenen, P.* ; Huysmans, M.A.* ; Holtermann, A.* ; Troiano, R.P.* ; Mork, P.J.* ; Krokstad, S.* ; Clays, E.* ; de Bacquer, D.* ; Aadahl, M.* ; Kårhus, L.L.* ; Sjøl, A.* ; Bo Andersen, L.* ; Kauhanen, J.* ; Voutilainen, A.* ; Pulsford, R.* ; Stamatakis, E.* ; Goldbourt, U.* ; Peters, A. ; Thorand, B. ; Rosengren, A.* ; Björck, L.* ; Sprow, K.* ; Franzon, K.* ; Rodríguez-Barranco, M.* ; Luján-Barroso, L.* ; Alfredsson, L.* ; Bahls, M.* ; Ittermann, T.* ; Wanner, M.* ; Bopp, M.* ; Marott, J.L.* ; Schnohr, P.* ; Nordestgaard, B.G.* ; Dalene, K.E.* ; Ekelund, U.* ; Clausen, J.* ; Jensen, M.T.* ; Petersen, C.B.* ; Krause, N.* ; Twisk, J.* ; van Mechelen, W.* ; van der Beek, A.J.*

Should workers be physically active after work? Associations of leisure-time physical activity with cardiovascular and all-cause mortality across occupational physical activity levels-An individual participant data meta-analysis.

J. Sport Health Sci. 14:100987 (2024)
Article in press DOI PMC
Creative Commons Lizenzvertrag
BACKGROUND: There is insufficient evidence to provide recommendations for leisure-time physical activity among workers across various occupational physical activity levels. This study aimed to assess the association of leisure-time physical activity with cardiovascular and all-cause mortality across occupational physical activity levels. METHODS: This study utilized individual participant data from 21 cohort studies, comprising both published and unpublished data. Eligibility criteria included individual-level data on leisure-time and occupational physical activity (categorized as sedentary, low, moderate, and high) along with data on all-cause and/or cardiovascular mortality. A 2-stage individual participant data meta-analysis was conducted, with separate analysis of each study using Cox proportional hazards models (Stage 1). These results were combined using random-effects models (Stage 2). RESULTS: Higher leisure-time physical activity levels were associated with lower all-cause and cardiovascular mortality risk across most occupational physical activity levels, for both males and females. Among males with sedentary work, high compared to sedentary leisure-time physical activity was associated with lower all-cause (hazard ratios (HR) = 0.77, 95% Confidence interval(95%CI): 0.70-0.85) and cardiovascular mortality (HR = 0.76, 95%CI: 0.66-0.87) risk. Among males with high levels of occupational physical activity, high compared to sedentary leisure-time physical activity was associated with lower all-cause (HR = 0.84, 95%CI: 0.74-0.97) and cardiovascular mortality (HR = 0.79, 95%CI: 0.60-1.04) risk, while HRs for low and moderate levels of leisure-time physical activity ranged between 0.87 and 0.97 and were not statistically significant. Among females, most effects were similar but more imprecise, especially in the higher occupational physical activity levels. CONCLUSION: Higher levels of leisure-time physical activity were generally associated with lower mortality risks. However, results for workers with moderate and high occupational physical activity levels, especially women, were more imprecise. Our findings suggests that workers may benefit from engaging in high levels of leisure-time physical activity, irrespective of their level of occupational physical activity.
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Publication type Article: Journal article
Document type Review
Keywords Individual Participant Data ; Job Demands ; Mortality ; Physical Activity Paradox; Heart-disease; Follow-up; Activity Paradox; Risk; Men; Health; Exercise; Domains; Adults; Ipd
Language english
Publication Year 2024
HGF-reported in Year 2024
ISSN (print) / ISBN 2095-2546
e-ISSN 2213-2961
Journal Journal of Sport and Health Science
Quellenangaben Volume: 14, Issue: , Pages: , Article Number: 100987 Supplement: ,
Publisher Elsevier
Publishing Place Editorial Board, 650 Qingyuanhuan Rd, Shanghai, 200438, Peoples R China
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
POF-Topic(s) 30202 - Environmental Health
Research field(s) Genetics and Epidemiology
PSP Element(s) G-504000-010
G-504000-002
Grants International Agency for Research on Cancer (IARC)
Helmholtz Zentrum Munchen-German Research Center for Environmental Health - German Federal Ministry of Education and Research (BMBF)
Swedish Research Council
Federal Ministry for Education and Research (BMBF)
ZonMw
Netherlands Organization for Health Research and Development
Murcia and Navarra
Regional Government of Murcia and Navarra
Regional Government of Basque Country
Regional Government of Asturias
Regional Government of Andalucia
Health Research Fund (FIS) -Instituto de Salud Carlos III (ISCIII)
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London
State of Bavaria
DOI 10.1016/j.jshs.2024.100987
WOS ID 001403196800001
PubMed ID 39277081
Erfassungsdatum 2024-10-15
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