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Ponce-de-Leon, M.* ; Wang-Sattler, R. ; Peters, A. ; Rathmann, W.* ; Grallert, H. ; Artati, A. ; Prehn, C. ; Adamski, J. ; Meisinger, C.* ; Linseisen, J.*

Stool and blood metabolomics in the metabolic syndrome: A cross-sectional study.

Metabolomics 20:105 (2024)
Publ. Version/Full Text DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
INTRODUCTION/OBJECTIVES: Changes in the stool metabolome have been poorly studied in the metabolic syndrome (MetS). Moreover, few studies have explored the relationship of stool metabolites with circulating metabolites. Here, we investigated the associations between stool and blood metabolites, the MetS and systemic inflammation. METHODS: We analyzed data from 1,370 participants of the KORA FF4 study (Germany). Metabolites were measured by Metabolon, Inc. (untargeted) in stool, and using the AbsoluteIDQ® p180 kit (targeted) in blood. Multiple linear regression models, adjusted for dietary pattern, age, sex, physical activity, smoking status and alcohol intake, were used to estimate the associations of metabolites with the MetS, its components and high-sensitivity C-reactive protein (hsCRP) levels. Partial correlation and Multi-Omics Factor Analysis (MOFA) were used to investigate the relationship between stool and blood metabolites. RESULTS: The MetS was significantly associated with 170 stool and 82 blood metabolites. The MetS components with the highest number of associations were triglyceride levels (stool) and HDL levels (blood). Additionally, 107 and 27 MetS-associated metabolites (in stool and blood, respectively) showed significant associations with hsCRP levels. We found low partial correlation coefficients between stool and blood metabolites. MOFA did not detect shared variation across the two datasets. CONCLUSIONS: The MetS, particularly dyslipidemia, is associated with multiple stool and blood metabolites that are also associated with systemic inflammation. Further studies are necessary to validate our findings and to characterize metabolic alterations in the MetS. Although our analyses point to weak correlations between stool and blood metabolites, additional studies using integrative approaches are warranted.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Blood Metabolomics ; Metabolic Syndrome ; Stool Metabolomics ; Systemic Inflammation; Gut Microbiota; Acid-metabolism; Bile-acids; Plasma
ISSN (print) / ISBN 1573-3882
e-ISSN 1573-3890
Journal Metabolomics
Quellenangaben Volume: 20, Issue: 5, Pages: , Article Number: 105 Supplement: ,
Publisher Springer
Publishing Place New York, NY
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Translational Genomics (ITG)
Institute of Epidemiology II (EPI2)
CF Metabolomics & Proteomics (CF-MPC)
Institute of Experimental Genetics (IEG)
Grants Projekt DEAL
Ludwig-Maximilians-Universitat Munchen, Germany
Munich Center of Health Sciences (MC-Health)
State of Bavaria
German Ministry of Education and Research (BMBF)
Helmholtz Munich - German Research Center for Environmental Health