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Open Access Green as soon as Postprint is submitted to ZB.
Monitoring of glucocorticoid therapy by assessment of CD14(+)CD16(+) monocytes: A case report.
Immunobiology 213, 909-916 (2008)
Bronchiolitis obliterans with organizing pneumonia (BOOP) is a disease affecting small airways and alveoli. It is characterized by interstitial inflammation rich in foamy macrophages and by fibroblastic connective tissue expanding into the airway and alveolar lumen. We report herein on a 54-year-old male BOOP patient who was treated with glucocorticoids (GCs) and who over a 5-year period had three relapses. At diagnosis the patient showed elevated CD14(+)CD16(+) monocyte numbers (85cells/mul) and increased serum C-reactive protein (CRP) levels (29.4mg/l). With GC therapy both parameters decreased within a few days. Diagnosis of relapse was preceded by a rise in CD14(+)CD16(+) monocyte numbers and in CRP levels which again responded to GC treatment. We conclude that determination of CD14(+)CD16(+) monocytes is a useful marker for monitoring of BOOP diagnosis and GC therapy.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
BOOP; Glucocorticoids; Monocyte subpopulations; CRP
ISSN (print) / ISBN
0171-2985
e-ISSN
1878-3279
Quellenangaben
Volume: 213,
Issue: 9-10,
Pages: 909-916
Publisher
Urban & Fischer
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
CCG Inflammatory Lung Diseases (CPC-KEL)