He, Y.* ; Zhang, M.* ; Ju, Y.* ; Yu, Z.* ; Lv, D.* ; Sun, H.* ; Yuan, W.* ; He, F.* ; Zhang, J.* ; Li, H.* ; Li, J.* ; Wang-Sattler, R. ; Li, Y.* ; Zhang, G.* ; Xie, L.*
     
    
        
dbDEPC 2.0: Updated database of differentially expressed proteins in human cancers.
    
    
        
    
    
        
        Nucleic Acids Res. 40, D964-D971 (2012)
    
    
    
      
      
	
	    A large amount of differentially expressed proteins (DEPs) have been identified in various cancer proteomics experiments, curation and annotation of these proteins are important in deciphering their roles in oncogenesis and tumor progression, and may further help to discover potential protein biomarkers for clinical applications. In 2009, we published the first database of DEPs in human cancers (dbDEPCs). In this updated version of 2011, dbDEPC 2.0 has more than doubly expanded to over 4000 protein entries, curated from 331 experiments across 20 types of human cancers. This resource allows researchers to search whether their interested proteins have been reported changing in certain cancers, to compare their own proteomic discovery with previous studies, to picture selected protein expression heatmap across multiple cancers and to relate protein expression changes with aberrance in other genetic level. New important developments include addition of experiment design information, advanced filter tools for customer-specified analysis and a network analysis tool. We expect dbDEPC 2.0 to be a much more powerful tool than it was in its first release and can serve as reference to both proteomics and cancer researchers.
	
	
	    
	
       
      
	
	    
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        Publication type
        Article: Journal article
    
 
    
        Document type
        Scientific Article
    
 
    
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        Keywords
        Proteomics; Pathways; Genes; Cells; Index; MYC
    
 
    
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        Language
        english
    
 
    
        Publication Year
        2012
    
 
    
        Prepublished in Year
        
    
 
    
        HGF-reported in Year
        2012
    
 
    
    
        ISSN (print) / ISBN
        0305-1048
    
 
    
        e-ISSN
        1362-4962
    
 
    
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	    Volume: 40,  
	    Issue: DI,  
	    Pages: D964-D971 
	    Article Number: ,  
	    Supplement: ,  
	
    
 
    
        
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            Oxford University Press
        
 
        
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        Reviewing status
        Peer reviewed
    
 
     
    
        POF-Topic(s)
        30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
    
 
    
        Research field(s)
        Genetics and Epidemiology
    
 
    
        PSP Element(s)
        G-504200-003
    
 
    
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        Erfassungsdatum
        2012-02-28