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Queiroga, A.P.R.* ; Souza, G.F.P.* ; Paschoal, J.A.R.* ; Salles, A.G.* ; Schloter, M. ; Assane, I.M.* ; Pilarski, F.* ; Gotardo, A.T.* ; Górniak, S.L.* ; Rath, S.*

Detection and analysis of florfenicol residues and metabolites in nile tilapia (Oreochromis niloticus) tissues post-oral administration in tropical waters.

J. Vet. Pharmacol. Ther., DOI: 10.1111/jvp.13485 (2024)
DOI PMC
Water temperature is a critical environmental parameter that significantly influences fish metabolism. This study assessed the metabolism of florfenicol (FF) in tilapia (Oreochromis niloticus) at water temperatures typical of tropical and subtropical regions. Fish were treated with FF by oral administration of a dose of 10 mg kg-1 bw for 10 consecutive days. Fish fillet, liver, and kidney were sampled during the treatment phase (1, 5, and 10 days) and posttreatment (1, 2, 3, and 5 days after the last FF administration). FF, florfenicol amine (FFA), monochloro florfenicol (FFCl), and florfenicol alcohol (FFOH) were determined in the sampled tissues using a validated LC-LC-MS/MS method. The highest FF, FFA, and FFOH concentrations were determined on day 5 during the treatment phase. For FF, the concentration order is kidney > liver > fillet, while for the metabolites FFOH and FFA, the order is liver > kidney > fillet. In fillet and liver, the concentrations of FFOH were higher than the FFA concentrations, indicating that FFOH was the primary metabolite in these tissues. FFCl was only quantified at concentrations lower than 90 μg kg-1 in all tissues. The results indicated that FF can be readily absorbed and rapidly eliminated in tilapia cultivated in warm water environments. This study revealed FFOH as the primary and most persistent metabolite in tilapia farmed in warm water, followed by FFA.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Nile Tilapia ; Florfenicol Metabolites ; Pharmacokinetics ; Residues ; Warm Water; Tandem Mass-spectrometry; Carp Carassius-auratus; Amine; Pharmacokinetics; Elimination; Depletion; Seawater; Fish
ISSN (print) / ISBN 0140-7783
e-ISSN 1365-2885
Journal Journal of Veterinary Pharmacology and Therapeutics
Publisher Wiley
Publishing Place 111 River St, Hoboken 07030-5774, Nj Usa
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Research Unit Comparative Microbiome Analysis (COMI)
Grants Fundao de Amparo Pesquisa do Estado de So Paulo