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Reinhard, W.* ; Stark, K.* ; Sedlacek, K.* ; Fischer, M.* ; Baessler, A.* ; Neureuther, K.* ; Weber, S.* ; Kaess, B.* ; Wiedmann, S.* ; Mitsching, S.* ; Lieb, W.* ; Erdmann, J.* ; Meisinger, C. ; Döring, A. ; Tolle, R.* ; Jeron, A.* ; Riegger, G.* ; Hengstenberg, C.*

Association between PPAR alpha gene polymorphisms and myocardial infarction.

Clin. Sci. 115, 301-308 (2008)
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Open Access Gold as soon as Publ. Version/Full Text is submitted to ZB.
PPAR alpha (peroxisome-proliferator-activated receptor alpha) regulates the expression of genes that are involved in lipid metabolism, tissue homoeostasis and inflammation. Consistent rodent and human studies suggest a link between PPAR alpha function and cardiovascular disease, qualifying PPAR alpha [PPARA in HUGO (Human Genome Organisation) gene nomenclature] as a candidate gene for coronary artery disease. In the present study, we comprehensively evaluated common genetic variations within the PPAR alpha gene and assessed their association with myocardial infarction. First, we characterized the linkage disequilibrium within the PPAR alpha gene in an initial case-control sample of 806 individuals from the Regensburg Myocardial Infarction Family Study using a panel of densely spaced SNPs (single nucleotide polymorphisms) across the gene. Single SNP analysis showed significant association with the disease phenotype [OR (odds ratio) = 0.74, P = 0.012, 95% CI (confidence interval) = 0.61-0.94 for rs135551]. Moreover, we identified a protective three-marker haplotype with an association trend for myocardial infarcition (OR = 0.76, P = 0.067, 95% CI = 0.56-1.02). Subsequently, we were able to confirm the single SNP and haplotype association results in an independent second case-control cohort with 667 cases from the Regensburg Myocardial Infarction Family Study and 862 control individuals from the WHO (World Health Organization) MONICA (Monitoring of Trends and Determinants in Cardiovascular Disease) Augsburg project (OR = 0.87, P = 0.046, 95% CI = 0.72-0.99 for rs135551 and OR = 0.80, P = 0.034, 95% CI = 0.65-0.98 for the three-marker haplotype respectively). From these cross-sectional association results, we provide evidence that common variations in the PPAR alpha gene may influence the risk of myocardial infarcition in a European population.
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Publication type Article: Journal article
Document type Scientific Article
Keywords cardiovascular risk; case-control study; gene polymorphism; myocardial infarction; peroxisome-proliferator-activated receptor alpha (PPAR alpha)
Language english
Publication Year 2008
HGF-reported in Year 2008
ISSN (print) / ISBN 0143-5221
e-ISSN 0143-5221
Journal Clinical Science
Quellenangaben Volume: 115, Issue: 9-10, Pages: 301-308 Article Number: , Supplement: ,
Publisher Portland Press
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
POF-Topic(s)
30202 - Environmental Health
Research field(s)
Genetics and Epidemiology
PSP Element(s) G-503900-004
G-504090-001
DOI 10.1042/CS20070391
Scopus ID 58149145325
Erfassungsdatum 2008-12-31
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